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The Effects of Spirulina (Arthrospira platensis) Supplementation on Anthropometric Indices, Blood Pressure, Sleep Quality, Mental Health, Fatigue Status, and Quality of Life in Patients with Ulcerative Colitis: A Randomized, Double-blinded, Placebo-controlled Trial
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  • sajjad Moradi,
  • Mehdi Zobeiri,
  • Awat Feizi,
  • Cain C. T. Clark ,
  • Mohammad Hassan Entezari
sajjad Moradi
Isfahan University of Medical Sciences

Corresponding Author:[email protected]

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Mehdi Zobeiri
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Awat Feizi
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Cain C. T. Clark
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Mohammad Hassan Entezari
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Background: An emerging body of evidence has highlighted the protective role of spirulina in human health. Thus, we conducted a randomized controlled trial to discern the effects of spirulina supplementation on anthropometric indices, blood pressure, sleep quality, mood, fatigue status, and quality of life among ulcerative colitis patients. Methods: Eighty participants with ulcerative colitis were randomly allocated to receive, either, 1 g/day (two 500 mg capsules) spirulina (n=40) or placebo (n=40), in a clinical trial for eight weeks. Dietary intake, physical activity, sleep quality, mental health, fatigue status, and quality, were assessed for each participant at baseline and trial cessation. Anthropometric indices and blood pressure were also assessed. Results: Seventy-three participants completed the intervention. Our results revealed that spirulina supplementation significantly reduced sleep disturbances (p=0.03), while no significant changes occurred in the sleep quality score or other sleep parameters, vs. the placebo group (p> 0.05). Furthermore, a significant reduction in stress score (p=0.04) and increase in quality of life (p=0.03) was detected, but not anxiety, depression, or fatigue scores (p> 0.05). Additionally, anthropometric indices and blood pressure did not significantly change (p> 0.05). Conclusion: An improved quality of life was observed among ulcerative colitis patients following spirulina supplementation, which could be attributed to improved sleep disturbance and stress status. Further clinical studies, with longer duration interventions and suitably powered sample sizes, are necessary to p elucidate the veracity of our findings.
26 Mar 2021Submitted to International Journal of Clinical Practice
28 Mar 2021Submission Checks Completed
28 Mar 2021Assigned to Editor
31 Mar 2021Reviewer(s) Assigned
15 Apr 2021Review(s) Completed, Editorial Evaluation Pending
12 May 20211st Revision Received
13 May 2021Submission Checks Completed
13 May 2021Assigned to Editor
13 May 2021Review(s) Completed, Editorial Evaluation Pending
16 May 2021Reviewer(s) Assigned
06 Jun 2021Editorial Decision: Accept