Epigenetic evidence of malignant carcinoma and skin melanoma neoplasms
concomitantly in the thyroid
The study investigates the case of a total thyroidectomy, where after
dissection multiple nodules showed two malignant patterns by
immunohistochemistry. Molecular analysis based on DNA methylation
profile was used to further inspect the origin of the coexisting
neoplasms. We confirmed the presence of malignant skin melanoma
involving medullary thyroid cancer.