loading page

Spatial and Temporal Variability of Rotational, Focal and Irregular Activity: Practical Implications for Mapping of Atrial Fibrillation
  • +4
  • Michael Pope,
  • Pawel Kuklik,
  • Andre Briosa e Gala,
  • Milena Leo,
  • Michael Mahmoudi,
  • John Paisey,
  • Tim Betts
Michael Pope
Oxford University Hospitals NHS Foundation Trust

Corresponding Author:[email protected]

Author Profile
Pawel Kuklik
Asklepios Kliniken Hamburg GmbH
Author Profile
Andre Briosa e Gala
Oxford University Hospitals NHS Foundation Trust
Author Profile
Milena Leo
Oxford University Hospitals NHS Foundation Trust
Author Profile
Michael Mahmoudi
University of Southampton Faculty of Medicine
Author Profile
John Paisey
University Hospital Southampton
Author Profile
Tim Betts
Oxford University Hospitals NHS trust
Author Profile


Background Charge density mapping of atrial fibrillation (AF) reveals dynamic patterns of localised rotational activation (LRA), irregular activation (LIA) and focal firing (FF). Their spatial stability, conduction characteristics and the optimal duration of mapping required to reveal these phenomena and has not been explored. Methods Bi-atrial mapping of AF propagation was undertaken and variability of activation patterns quantified up to a duration of 30-seconds(s). The frequency of each pattern was quantified at each vertex of the chamber over 2 separate 30s recordings prior to ablation and R2 calculated to quantify spatial stability. Regions with the highest frequency were identified at increasing time durations and compared to the result over 30s using Cohen’s kappa. Properties of regions with the most stable patterns were assessed during sinus rhythm and extrastimulus pacing. Results In twenty-one patients, 62 paired LA and RA maps were obtained. LIA was highly spatially stable with R2 between maps of 0.83(0.71-0.88) compared to 0.39(0.24-0.57) and 0.64(0.54-0.73) for LRA and FF, respectively. LIA was also most temporally stable with a kappa of >0.8 reached by 12s. LRA showed greatest variability with kappa>0.8 only after 22s. Regions of LIA were of normal voltage amplitude (1.09mv) but showed increased conduction heterogeneity during extrastimulus pacing (p=0.0480). Conclusion Irregular activation patterns characterised by changing wavefront direction are temporally and spatially stable in contrast with rotational patterns that are transient with least spatial stability. Focal activation appears of intermediate stability. Regions of LIA show increased heterogeneity following extrastimulus pacing and may represent fixed anatomical substrate.
12 Mar 2021Submitted to Journal of Cardiovascular Electrophysiology
15 Mar 2021Submission Checks Completed
15 Mar 2021Assigned to Editor
22 Mar 2021Reviewer(s) Assigned
15 Apr 2021Review(s) Completed, Editorial Evaluation Pending
19 Apr 2021Editorial Decision: Revise Minor
05 May 20211st Revision Received
07 May 2021Submission Checks Completed
07 May 2021Assigned to Editor
07 May 2021Reviewer(s) Assigned
24 May 2021Review(s) Completed, Editorial Evaluation Pending
25 May 2021Editorial Decision: Accept