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Sustained pharyngeal inflation on upper airway effects in infants---flexible bronchoscopy measurement
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  • Wen-Jue Soong,
  • Chia-Feng Yang,
  • Chieh-Ho Chen,
  • Yu-Sheng Lee,
  • Chien-Heng Lin,
  • Pei-Chen Tsao,
  • Nitin Dhochak
Wen-Jue Soong
Children;s Hospital, Taichung China Medical University

Corresponding Author:[email protected]

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Chia-Feng Yang
Taipei veterans general hospital
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Chieh-Ho Chen
China Medical University
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Yu-Sheng Lee
Taipei Veterans General Hospital
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Chien-Heng Lin
China Medical University Hospital
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Pei-Chen Tsao
Veteran general hospital, Taipei, Taiwan (ROC)
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Nitin Dhochak
All India Institute of Medical Sciences
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OBJECTIVE: Sustained pharyngeal inflation (SPI) with pharyngeal oxygen and nose-close (PhO2-NC) can create positive peak inflation pressure (PIP) inside the pharyngolaryngeal space (PLS). This study measured and compared effects of four different SPI durations in the PLS. METHOD: In this prospective observational study, 20 consecutive infants aged less than 3 years, scheduled for elective flexible-bronchoscopy were enrolled. SPI was performed twice in four different durations (0, 1, 3 and 5 seconds) sequentially in each infant. PIP was measured for each SPI in the pharynx, and simultaneously took images at two locations of oropharynx and supra-larynx. Infants’ demographic details and PIP levels, lumen expansion scores and images of PLS were measured and analyzed. RESULTS: Twenty infants with 40 measurements were collected. The mean (SD) age and weight were 11.6 (9.1) months and 6.8 (2.4) kg, respectively. The measured mean (SD) pharyngeal PIPs were 4.1 (3.3), 21.9 (7.0), 42.2 (12.3) and 65.5 (18.5) cm H2O at SPI duration of 0, 1, 3 and 5 seconds, respectively; which showed significant positive association (p<0.001). At assigned locations, the corresponding PLS images also show significant increase in lumen expansion scores and number of detected lesions with increase in SPI duration (p<0.001). The mean (SD) study time was 5.7 (1.2) minutes. No study related complication was noted. CONCLUSIONS: SPI with PhO2-NC up to 5 seconds is a simple, safe and feasible clinical ventilation modality. It may provide enough PIP to expand the PLS and facilitate flexible-bronchoscopy performance in infants.
14 Mar 2021Submitted to Pediatric Pulmonology
16 Mar 2021Submission Checks Completed
16 Mar 2021Assigned to Editor
18 Mar 2021Reviewer(s) Assigned
19 Apr 2021Review(s) Completed, Editorial Evaluation Pending
19 Apr 2021Editorial Decision: Revise Major
17 May 20211st Revision Received
20 May 2021Assigned to Editor
20 May 2021Submission Checks Completed
20 May 2021Reviewer(s) Assigned
01 Jun 2021Review(s) Completed, Editorial Evaluation Pending
08 Jun 2021Editorial Decision: Revise Minor
12 Jun 20212nd Revision Received
28 Jun 2021Submission Checks Completed
28 Jun 2021Assigned to Editor
28 Jun 2021Reviewer(s) Assigned
01 Jul 2021Review(s) Completed, Editorial Evaluation Pending
20 Jul 2021Editorial Decision: Accept