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Scoping review on the epidemiology, diagnostics, and clinical significance of porcine astroviruses
  • Gaurav Rawal,
  • Daniel Linhares
Gaurav Rawal
Iowa State University

Corresponding Author:[email protected]

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Daniel Linhares
Iowa State University
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Porcine astroviruses (PoAstVs) have been reported globally and are divided into at least five distinct lineages (PoAstV1-PoAsV5). The primary objective of this study was to summarize the scientific literature about the frequency of detection, associated clinical presentations, and type of samples and diagnostic tools used for the detection of porcine astroviruses. The secondary objective was to summarize the body of knowledge about the causal role in disease of PoAstVs using the Bradford Hill framework. A search was conducted using Centre for Biosciences and Agriculture International (CABI), MEDLINE, American Association of Swine Veterinarians (AASV) Swine Information Library (SIL) abstracts, swine conferences including American College of Veterinary Pathologists (ACVP), and American Association of Veterinary Laboratory Diagnosticians (AAVLD). From 168 studies identified by the search, 29 studies were eligible. Results indicated that 69% (20/29) of the literature on PoAstVs has been published between 2011 and 2018. Of 29 papers, 52% were detection studies (15 of 29) and 48% (14 of 29) were case-control studies. Seventy-two percent (21 of 29) reported differential diagnosis and 10% (3 of 29) reported histologic lesions, out of which 67% (2 of 3) associated the detection of PoAstV3 with development of polioencephalomyelitis. PCR-based assays were the most common diagnostic tools. Keywords: Swine, Astrovirus, Scoping review, Bradford Hill, PoAstV detection
25 Jan 2021Submitted to Transboundary and Emerging Diseases
26 Jan 2021Submission Checks Completed
26 Jan 2021Assigned to Editor
07 Feb 2021Reviewer(s) Assigned
03 Mar 2021Review(s) Completed, Editorial Evaluation Pending
06 Mar 2021Editorial Decision: Revise Major
10 Mar 20211st Revision Received
10 Mar 2021Assigned to Editor
10 Mar 2021Submission Checks Completed
13 Mar 2021Reviewer(s) Assigned
04 Apr 2021Review(s) Completed, Editorial Evaluation Pending
11 Apr 2021Editorial Decision: Revise Minor
13 Apr 20212nd Revision Received
14 Apr 2021Submission Checks Completed
14 Apr 2021Assigned to Editor
17 Apr 2021Reviewer(s) Assigned
21 Apr 2021Review(s) Completed, Editorial Evaluation Pending
21 Apr 2021Editorial Decision: Accept
May 2022Published in Transboundary and Emerging Diseases volume 69 issue 3 on pages 974-985. 10.1111/tbed.14123