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Myocarditis associated with Covid-19 disease: a systematic review of published Case reports and Case series
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  • Sawai Singh Rathore,
  • Gianpier Alonzo Rojas,
  • Manush Sondhi,
  • Suveenkrishna Pothuru,
  • Reshma Pydi,
  • Neeraj Kancherla ,
  • Romil Singh,
  • Noman Khurshid Ahmed,
  • Jill Shah,
  • Sohaib Tousif,
  • Unaiza Tariq Baloch ,
  • Qingqing Wen
Sawai Singh Rathore
Dr Sampurnanand Medical College

Corresponding Author:[email protected]

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Gianpier Alonzo Rojas
School of medicine,Universidad Peruana Cayetano Heredia, Lima
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Manush Sondhi
Kasturba Medical College Manipal
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Suveenkrishna Pothuru
Ascension Via Christi Hospital in Manhattan
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Reshma Pydi
Andhra Medical College
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Neeraj Kancherla
Andhra Medical College
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Romil Singh
Mayo Clinic Rochester
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Noman Khurshid Ahmed
Dow Medical College
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Jill Shah
Tambov state University named after G.R.Derzhavin
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Sohaib Tousif
Ziauddin Medical University
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Unaiza Tariq Baloch
The Aga Khan University Hospital
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Qingqing Wen
University of California Los Angeles, Fielding School of Public Health,
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Background: Covid-19 is an extremely contagious illness caused by the severe acute respiratory syndrome (SARS-CoV-2) virus. Although this disease primarily involves pulmonary tissue, rapidly advancing research has established cardiac involvement in Covid-19 patients. Objective: This systematic review article aimed to compile and illustrate clinical characteristics, diagnostic findings, management, and outcomes manifesting in myocarditis linked with Covid-19. Methods: A literature search was accomplished for published eligible articles with MEDLINE/PubMed and Embase databases. All eligible case reports and case series were included from around the world without any language restrictions. For this review, inclusion criteria were laboratory-confirmed SARS-CoV-2 infection cases reporting a diagnosis of acute myocarditis. Results: Data from 41 studies describing myocarditis in 42 Covid-19 patients was obtained. The median age of these patients was 43.4 years, with 71.4% of them being male. Fever was the most prevalent presenting symptoms seen in 57% of patients. Hypertension was the most pervasive comorbidity accompanying these patients. Cardiac biomarkers troponin and Brain natriuretic peptide (BNP) were raised in almost 90% and 87% of patients, respectively. Electrocardiogram findings were Non-specific and included ST-segment and T-wave changes. The most prevalent histopathological feature appreciated was diffuse lymphocytic inflammatory infiltrates. Antivirals and corticosteroids were the most frequently used medications. About 38% of patients also needed vasopressor assistance. Out of 42 patients, 67% recovered, and eight died. Conclusion: Due to the risk of a sudden worsening of patients conditions and myocarditis association with considerable mortality and morbidity, a knowledge of this cardiac complication of Covid-19 disease is crucial for healthcare professionals.
25 Jan 2021Submitted to International Journal of Clinical Practice
25 Jan 2021Submission Checks Completed
25 Jan 2021Assigned to Editor
01 Feb 2021Reviewer(s) Assigned
23 Feb 2021Review(s) Completed, Editorial Evaluation Pending
18 Mar 20211st Revision Received
19 Mar 2021Assigned to Editor
19 Mar 2021Submission Checks Completed
30 Apr 2021Reviewer(s) Assigned
07 May 2021Review(s) Completed, Editorial Evaluation Pending
11 May 20212nd Revision Received
12 May 2021Submission Checks Completed
12 May 2021Assigned to Editor
12 May 2021Review(s) Completed, Editorial Evaluation Pending
24 May 2021Editorial Decision: Accept