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Evaluation of non-invasive arterial stiffness parameters and their relationship with physical activity, anthropometric indices and lipid profiles in healthy middle-aged adults: results of the PERSIAN cohort study
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  • Mohammad Nosrati-Oskouie,
  • Sajjad Arefinia,
  • Saeed Eslami Hasan Abadi,
  • Abdolreza Norouzy,
  • Hamed Khedmatgozar,
  • Nazanin Sadat Aghili-Moghaddam,
  • Maryam Alinezhad-Namaghi,
  • Mohammad Reza Shadmand Foumani Moghadam,
  • Reza Rezvani
Mohammad Nosrati-Oskouie
Tabriz University of Medical Sciences

Corresponding Author:[email protected]

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Sajjad Arefinia
Mashhad University of Medical Sciences
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Saeed Eslami Hasan Abadi
Mashhad University of Medical Sciences
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Abdolreza Norouzy
Mashhad University of Medical Sciences
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Hamed Khedmatgozar
Texas Tech University
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Nazanin Sadat Aghili-Moghaddam
Mashhad University of Medical Sciences
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Maryam Alinezhad-Namaghi
Mashhad University of Medical Sciences
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Mohammad Reza Shadmand Foumani Moghadam
Varastegan Institute for Medical Sciences
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Reza Rezvani
Mashhad University of Medical Sciences
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Background: Arterial stiffness (AS) indicates the initial stage of cardiovascular disease (CVD), which associated with modifiable and lifestyle risk factors. We aimed to examine the association of AS with anthropometric indices, lipid profiles, and physical activity. Methods: 658 healthy middle-aged adults selected and anthropometric indices (body mass index (BMI), waist circumferences (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), neck circumferences (NC), a body shape index (ABSI), body roundness index (BRI), body-fat mass (BFM), visceral-fat, fat-free mass(FFM), lipid profiles, and PA were measured. Arterial Stiffness measured by carotid-femoral pulse wave velocity (cf-PWV) and central augmentation index (cAIx). Results: Our results show, cf-PWV positively associated with TGs (β = 0.10, p = 0.01) and in anthropometric indices corelated with, WC (β = 0.11, p = 0.02), WHR (β = 0.09, p = 0.03), WHtR (β = 0.1, p = 0.02), and BRI (β = 0.09, p = 0.04). cAIx was independently positive association with cholesterol (β = 0.08, p = 0.03), WC (β = 0.1, p = 0.03), WHR (β = 0.09, p = 0.02), ABSI (β = 0.09, p = 0.01), BRI (β = 0.08, p = 0.05), visceral-fat area (β = 0.09, p = 0.03) and BFM (β = 0.08, p = 0.04) and negatively associated with PA (β = -0.08, p = 0.03). Conclusions: WC, WHR, and BRI were associated with both cf-PWV and cAIx. TGs and WHtR associated with cf-PWV, while cAIx was associated with ABSI, so improving these indices may be helpful to prevent CVD.
31 Dec 2020Submitted to International Journal of Clinical Practice
02 Jan 2021Submission Checks Completed
02 Jan 2021Assigned to Editor
02 Jan 2021Reviewer(s) Assigned
20 Mar 2021Review(s) Completed, Editorial Evaluation Pending
17 Apr 20211st Revision Received
19 Apr 2021Submission Checks Completed
19 Apr 2021Assigned to Editor
20 Apr 2021Reviewer(s) Assigned
25 Apr 2021Review(s) Completed, Editorial Evaluation Pending
26 Apr 2021Editorial Decision: Accept