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Comparative incidence and burden of respiratory viruses associated with hospitalization in adults in New York City
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  • William Sieling,
  • Connor Goldman,
  • Matthew Oberhardt,
  • Matthew Phillips,
  • Lynn Finelli,
  • Lisa Saiman
William Sieling
Columbia University Irving Medical Center

Corresponding Author:[email protected]

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Connor Goldman
Columbia University Irving Medical Center
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Matthew Oberhardt
NewYork-Presbyterian Hospital
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Matthew Phillips
Merck & Co Inc
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Lynn Finelli
Merck & Co Inc
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Lisa Saiman
Columbia University Irving Medical Center
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Background: Although the burden of influenza is well characterized, the burden of community-onset non-influenza respiratory viruses has not been systematically assessed. Understanding the severity and seasonality of non-influenza viruses, including human coronaviruses, will provide a better understanding of the overall disease burden from respiratory viruses that could better inform resource utilization for hospitals and highlight the value of preventative strategies, including vaccines. Methods: From October 2017 to September 2019, a retrospective study was performed in a pre-defined catchment area to estimate the population-based incidence of community-onset respiratory viruses associated with hospitalization. Included patients were >18 years old, resided in New York City, were hospitalized for >24 hours, and had a respiratory virus detected within 3 calendar-days of admission. Disease burden was measured by hospital length of stay (LOS), intensive care unit (ICU) admissions, and in-hospital mortality and compared among those with laboratory-confirmed influenza versus those with laboratory-confirmed non-influenza viruses (human coronaviruses, parainfluenza viruses, respiratory syncytial virus, human metapneumovirus, and adenovirus). Results: During the study period, 4,232 eligible patients were identified of whom 50.9% were >65 years of age. For each virus, the population-based incidence was highest for those >80 years of age. When compared to those with influenza viruses detected, those with non-influenza respiratory viruses detected (combined) had higher population-based incidence, significantly more ICU admissions, and higher in-house mortality. Conclusions: The burden of non-influenza respiratory viruses for hospitalized adults is substantial. Prevention and treatment strategies are needed for non-influenza respiratory viruses, particularly for older adults.
09 Dec 2020Submitted to Influenza and other respiratory viruses
10 Dec 2020Assigned to Editor
10 Dec 2020Submission Checks Completed
15 Dec 2020Editorial Decision: Revise Minor
28 Dec 20201st Revision Received
05 Jan 2021Submission Checks Completed
05 Jan 2021Assigned to Editor
05 Jan 2021Editorial Decision: Accept