Celastrol alleviates comorbid obesity and depression by directly binding
amygdala hnRNPA1 in a mouse model
Background and Purpose: Obesity and depression are highly comorbid and
far from effective treating. Celastrol was reported useful for obesity,
but its role in the obesity-depression comorbidity remains unknown. This
study aims to investigate the efficacy and associated mechanism of
celastrol in this comorbidity.