Epileptic Convulsions Probably Induced by Desloratadine, a
Second-generation H1-antihistamines are generally considered to be safe.
Here we describe a healthy boy who developed left-arm convulsions after
repeated exposure to a dry suspension of desloratadine combined with
Huatengzi granules. The boy had no family or disease history of
epilepsy, convulsions, or any other drug therapy. The Naranjo Adverse
Drug Reaction Probability Scale was used to determine that the
convulsions were probably related to desloratadine. Our findings suggest
that desloratadine (a second-generation H1-antihistamine) can cause
epileptic convulsions in healthy children, and so clinicians should be
vigilant of the possibility of central side effects.