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Rising trend in paediatric eosinophilic esophagitis incidence in Spain: results of a prospective study 2014-16
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  • Enrique La Orden Izquierdo,
  • Sonia Fernández Fernández,
  • Josefa Barrio Torres,
  • Enriqueta Román Riechmann,
  • Carolina Gutiérrez Junquera
Enrique La Orden Izquierdo
Hospital Universitario Infanta Elena

Corresponding Author:[email protected]

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Sonia Fernández Fernández
Severo Ochoa University Hospital
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Josefa Barrio Torres
Hospital Universitario de Fuenlabrada
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Enriqueta Román Riechmann
Hospital Universitario Clinica Puerta de Hierro
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Carolina Gutiérrez Junquera
Hospital Universitario Clinica Puerta de Hierro
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Objetives: The rate of eosinophilic esophagitis (EoE) diagnosis is increasing. This study aims to determine the incidence of EoE in the paediatric population residing in the southwestern Madrid and to analyse whether absolute monthly pollen counts, modified or not by the principal atmospheric pollutants, are associated with it. Methods: A prospective observational study was designed to calculate the incidence of EoE in children aged under 15 years who were diagnosed between September 2014 and August 2016 in twelve area hospitals. We collected clinical data, date of endoscopic diagnosis and the number of first-time endoscopies performed. Relative risk estimation was performed to assess the association between the incidence of diagnosis and monthly pollen counts and levels of atmospheric pollutants. Results: One hundred forty-eight patients were included. The most frequent symptoms were abdominal pain 42.57%, dysphagia 42.57% and impaction 39-86%. The average overall monthly incidence was 1.27 (0.41-2.67) cases/100,000 children and the annual average was 15.2. The overall analysis of the relationship between incidence and absolute monthly counts and air pollutants, corrected for the number of first-time endoscopies performed, revealed no statistically significant association. There was a higher frequency of diagnosis during the pollination period of Cupressaceae and during February and November (relative risk 1.67; p<0.01). Conclusions: This study confirms the high incidence of eosinophilic esophagitis and also suggest a period of higher incidence of diagnosis in the months of February and November as well as in the period of high pollination of Cupressaceae.
08 Nov 2020Submitted to Pediatric Allergy and Immunology
12 Nov 2020Reviewer(s) Assigned
24 Dec 2020Review(s) Completed, Editorial Evaluation Pending
31 Dec 2020Editorial Decision: Revise Major
14 Mar 20211st Revision Received
17 Mar 2021Review(s) Completed, Editorial Evaluation Pending
19 Mar 2021Reviewer(s) Assigned
07 Apr 2021Editorial Decision: Revise Minor
11 Apr 20212nd Revision Received
12 Apr 2021Review(s) Completed, Editorial Evaluation Pending
18 Apr 2021Reviewer(s) Assigned
24 Apr 2021Editorial Decision: Accept