Phylogeography of the Highly Pathogenic Avian Influenza H5N6 Virus
Determine Transmission from Guangdong Province, China to South Korea and
Japan by Wild Bids in 2016
The Goose/Guangdong lineage highly pathogenic avian influenza (HPAI)
clade 184.108.40.206 viruses have spilled over to wild birds and caused
transboundary epizootics. In 2016, the H5N6 subtype of clade 220.127.116.11
HPAI viruses was introduced to Korea and Japan by wild waterfowls.
However, the detailed geographic location of the origin of this outbreak
was not fully defined yet. In this study, the geographical origin of
this outbreak was estimated using phylogeographic analysis. The results
indicate that the H5N6 viruses of wild birds originated from a virus in
Guangdong province, China. In addition, Guangdong province was an
epicenter for H5N6 viruses, and multiple spillovers of viruses from
poultry into wild birds have been detected. Thus, to predict and prepare
for the next HPAI outbreak in Korea and Japan, viruses in Guangdong
province should be carefully monitored and investigated.