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Clinical and laboratory profile of patients with anaphylaxis to fire ant venom (Solenopsis sp) under specific subcutaneous immunotherapy
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  • Alexandra Watanabe,
  • Marcelo Ferreira,
  • Clóvis Galvão,
  • Jorge Kalil,
  • Keity Santos,
  • Fábio Castro
Alexandra Watanabe
University of Sao Paulo

Corresponding Author:[email protected]

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Marcelo Ferreira
University of Sao Paulo
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Clóvis Galvão
University of Sao Paulo
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Jorge Kalil
São Paulo University
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Keity Santos
School of Medicine of Sao Paulo University
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Fábio Castro
School of Medicine of the University of São Paulo
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Background: Anaphylaxis to fire ant venoms (Solenopsis sp) is a significant cause of systemic reaction caused by Hymenoptera stings in children. There are only a few reports about the safety and efficacy of specific immunotherapy. Objective: Evaluate clinical characteristics, IgE and IgG4 specific responses of patients undergoing immunotherapy with a whole-body extract of Solenopsis sp after one year of the maintenance phase. Materials and methods: Thirty-three patients were enrolled due to anaphylaxis by fire ant venom (Solenopsis sp) and underwent specific immunotherapy. They were assessed at baseline and one year after the beginning of the maintenance phase for skin test; specific venom IgE and IgG4 antibodies; tryptase. Results: All patients included presented a severe anaphylactic reaction. Although two patients (6.25%) presented a tryptase level higher than 11.4 ug/ml, systemic mastocytosis was ruled out. There was no relationship between the severity of the reaction with gender, tryptase level, atopy, previous reactions, the allergen’s concentration in the skin test or specific IgE level. There was an increase in the specific IgG4/IgE ratio between the two time points. Reactions were local, with only two mild systemic reactions during the build-up phase. Twenty patients had accidental stings during immunotherapy, with 3 presenting only urticaria. Conclusions: This study is unprecedented in evaluating clinical and laboratory data in the fire ant immunotherapy. Our results show that after one year of the maintenance phase, patients did not develop any severe reaction with only a few mild reactions and presented a significant production of specific IgG4.
05 Mar 2022Published in SN Comprehensive Clinical Medicine volume 4 issue 1. 10.1007/s42399-022-01150-z