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A Multicenter Study of Three-dimensional Echocardiographic Evaluation of Normal Pediatric Left Ventricular Volumes and Function with Automated Versus Semi-Automated Quantification
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  • Pei-Ni Jone,
  • Lisa Le,
  • Zhaoxing Pan,
  • Tim Colen,
  • Sachie Shigemitsu,
  • Nee Scze Khoo,
  • Benjamin Goot,
  • Anitha Parthiban,
  • David Harrild,
  • Alessandra Ferraro,
  • Gerald Marx
Pei-Ni Jone
Children's Hospital Colorado

Corresponding Author:[email protected]

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Lisa Le
Children's Hospital Colorado
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Zhaoxing Pan
University of Colorado Denver Children's Hospital Colorado Research Institute
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Tim Colen
Stollery Children's Hospital
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Sachie Shigemitsu
Stollery Children's Hospital
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Nee Scze Khoo
Stollery Children's Hospital
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Benjamin Goot
Childrens Wisconsin
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Anitha Parthiban
Children's Mercy Hospitals and Clinics
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David Harrild
Boston Children's Hospital
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Alessandra Ferraro
Boston Children s Hospital
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Gerald Marx
Boston Children's Hospital
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Abstract

Background: Three-dimensional echocardiography (3DE) evaluation of left ventricular (LV) volume and function in pediatrics compares favorably with cardiac magnetic resonance imaging. A multicenter trial with automated and semi-automated LV quantification allows for generation of normative data in large pediatric patients. The aims of this study were to evaluate the feasibility and reproducibility of measuring three-dimensional echocardiography (3DE) volumes and function in pediatric patients in a multicenter trial; to determine if automated software (without contouring edits) will improve the reproducibility in volume and function analysis; and thus establish normal z score values in this unique population. Methods: Six hundred and ninety-eight healthy children (ages 0 to 18 years) were recruited from 5 centers. Left ventricular (LV) 3DE was acquired from the 4-chamber view. A vendor independent software analyzed end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and ejection fraction (EF) using automated and semi-automated quantification. Feasibility and reproducibility were assessed. Body surface area (BSA) based z-scores were generated. Results: Feasibility was 79% (523/658). Reproducibility was good between centers using the semi-automated quantification. Reproducibility was decreased using the automated quantification. Therefore, Z-scores were generated for ESV, EDV, and SV using the semi-automated method. Conclusions: 3DE can reliably evaluate LV volumes and EF in pediatric patients at different centers. We report pediatric Z-scores for normal LV volumes using the semi-automated method. Further optimization of technology will be necessary for reliable use of fully automated quantification by 3DE in children.