Effect of the ionic antineoplastic agent Cytoreg on blood chemistry in
the Wistar rat model
- Katiusca Villasana,
- William Quintero,
- Yepsys Montero,
- Cristian Pino,
- Oscar Uzcátegui,
- Geizon Torres,
- Mariangel Prada,
- Lewis Pozo,
- William Bauta,
- William Jimenez
Katiusca Villasana
University of the Andes
Corresponding Author:anastipv@gmail.com
Author ProfileAbstract
Cytoreg is an ionic therapeutic agent comprising a mixture of
hydrochloric, sulfuric, phosphoric, hydrofluoric, oxalic, and citric
acids. In diluted form, it has demonstrated efficacy against human
cancers in vitro and in vivo. Although Cytoreg is well tolerated in
mice, rats, rabbits, and dogs by oral and intravenous administration,
its mechanism of action is not understood. The acidic nature of Cytoreg
could potentially disrupt the pH and levels of ions and dissolved gases
in the blood. Here, we report the effects of the intravenous
administration of Cytoreg on the arterial pH, oxygen and carbon dioxide
pressures, and bicarbonate, sodium, potassium, and chloride
concentrations. Our results demonstrate that Cytoreg increases oxygen
levels and can be used from a therapeutic point of view.