Socioeconomic, comorbidity, lifestyle and quality of life comparisons
between chronic rhinosinusitis phenotypes: Data from the National
Chronic Rhinosinusitis Epidemiology Study
Background: Chronic rhinosinusitis (CRS) is a heterogenous group of
inflammatory sinonasal disorders with key defining symptoms, but
traditionally separated into phenotypes by clinical/endoscopic findings.
It is not known if the two phenotypes have differing socioeconomic,
co-morbidity and lifestyle differences. Objective: This analysis of the
Chronic Rhinosinusitis Epidemiology Study (CRES) database sought to
analyse any key differences in the socioeconomic variables between those
with CRS with nasal polyps (CRSwNPs) and those without nasal polyps
(CRSsNP). We also sought to analyse differences in comorbidities,
lifestyle and quality of life. Methods: Patients with a confirmed
diagnosis of CRS in secondary and tertiary care outpatient settings were
invited to participate in a questionnaire based case-control study.
Variables included demographics, comorbidities, socioeconomic factors,
lifestyle factors and health related quality of life. Results: A total
of 1204 patients’ data were analysed; 553 CRSsNP and 651 CRSwNP
participants. The key socioeconomic variables did not demonstrate any
notable differences, nor did lifestyle variables other than alcohol
consumption being higher in those with CRSwNP (p=0.032). Aside from
confirmation of asthma being more common in CRSwNP, it was notable that
this group complained less of URTIs and CRSsNP participants showed
evidence of lower HRQoL scores in respect of body pain (p=0.001).
Conclusions: Patients with CRSwNP experience higher rates of asthma and
lower rates of URTIs but otherwise do not demonstrate significant
socioeconomic, comorbidity, lifestyle or quality of life issues other
than for body pain and alcohol consumption.