A Novel Finding in Pediatric Leiomyosarcoma: Expanding Spectrum of FGFR
rearrangements in Childhood Cancers
Non Rhabdomyosarcoma Soft Tissue Sarcomas (NRSTS) are rare in the
pediatric age group, accounting for 1-7% of all pediatric tumors.
Leiomyosarcoma, a subtype of NRSTS, is exceedingly rare in pediatric
population. Due to the rarity of this condition, management is
extrapolated from other common NRSTS which involves surgery,
chemotherapy and radiation. Chemotherapy is not very effective in
management of pediatric leiomyosarcoma and molecular information may
help guide targeted therapies. We describe a patient with a FGFR1-TACC1
gene rearrangement which, based on other models, predicts for
sensitivity to FGFR inhibitors.