Cannabinoid Receptor and Inflammation
- Newman Osafo,
- Oduro Yeboah,
- Aaron Antwi,
- George Ainooson
Oduro Yeboah
Kwame Nkrumah University of Science and Technology
Author ProfileAaron Antwi
Kwame Nkrumah University of Science and Technology
Author ProfileGeorge Ainooson
Kwame Nkrumah University of Science and Technology
Author ProfileAbstract
The eventual discovery of endogenous cannabinoid receptors CB1 and CB2
and their endogenous ligands has generated interest with regards to
finally understanding the endocannabinoid system. Its role in the normal
physiology of the body and its implication in pathological states such
as cardiovascular diseases, neoplasm, depression and pain have been
subjects of scientific interest. In this review the authors focus on the
endogenous cannabinoid pathway, the critical role of cannabinoid
receptors in signaling and mediation of neurodegeneration and other
inflammatory responses as well as its potential as a drug target in the
amelioration of some inflammatory conditions. Though the exact role of
the endocannabinoid system is not fully understood, the evidence found
leans heavily towards a great potential in exploiting both its central
and peripheral pathways in disease management. Cannabinoid therapy has
already shown great promise in several preclinical and clinical trials.