Cardiogenic shock on 5-fluoruracile: a rare, fulminant and transient
disease that deserves attention
Five-fluorouracil (5-FU) and platins remain a first line treatment in
oncology with a potential of cardiovascular toxicity. We identified two
cases of acute severe cardiac toxicity treated with a combination of 5FU
(different production batch) and platins at three months interval at two
different institutions referred to our cardio-oncology services. Both
cases had similar clinical presentation, favorable outcomes and
identical cardiac magnetic imaging scans at follow-up. Mechanism was
direct myocardial toxicity in the case with endomyocardial biopsy.
Circulatory support as a bridge to recovery should be considered in the
case of untreatable cardiogenic shock likely due to 5-FU.