Device-related thrombus formation in patients received one-stop
intervention for nonvalvular atrial fibrillation:A systemic review and
meta-analysis
Abstract
Introduction:Combing CA and LAAO into one procedure has become a
prospective measurement for patients with nonvalvular atrial
fibrillation. Data on the incidence of DRT in one-stop intervention,
treatment strategy, and its clinical implications are limited.
Methods:A meta-analysis of observational studies evaluating the
incidence, treatment strategy, and clinical implications of DRT was
conducted. Results:Overall 21 studies describing DRT events and one
case were included in the study. The pooled incidence of DRT in one-stop
intervention was 1.2% (range from 0% to 7.3%, 95%CI 0.7%-1.8%,
I2=0). 56.25% of events were diagnosed in the first three months after
the procedure. All cases were diagnosed with a trans-esophagus
echocardiogram (TEE). All patients diagnosed with DRT were prescribed
anticoagulants. And 63% (12/19) events were reported with complete
thrombus resolution. Anticoagulation duration varied greatly from 30d to
6m. Unknown clinical events were reported relating to DRT.
Conclusions:DRT is an uncommon complication of the one-stop
intervention. It occurs mainly in the first three months after the
procedure. Anticoagulation seems to be an appropriate method for
dissolving thrombus.