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Mechanisms and grading of nocturia: Results from a multicenter prospective study
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  • Ozan Bozkurt,
  • Bora Irer,
  • Fuat Kizilay,
  • Oguzcan Erbatu,
  • Volkan Sen,
  • Onder Cinar,
  • Sakir Ongun,
  • Ahmet Cihan,
  • Turan Ozdemir,
  • Dogu Tasdemir,
  • Oktay Ucer
Ozan Bozkurt
Dokuz Eylul Universitesi Tip Fakultesi

Corresponding Author:[email protected]

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Fuat Kizilay
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Oguzcan Erbatu
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Volkan Sen
Manisa State Hospital
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Onder Cinar
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Sakir Ongun
Balikesir University
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Ahmet Cihan
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Turan Ozdemir
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Dogu Tasdemir
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Oktay Ucer
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Objective: To identify pathophysiological mechanisms of nocturia and the correlation of these mechanisms with nocturia severity. Methodology: After approval by the local ethics committee, all patients with nocturia (≥1 nocturnal void/night) were included and filled the overactive bladder questionnaire (OABq), nocturia quality of life (N-QoL), ICIQ-MLUTS (male), ICIQ-FLUTS (female) and 3-day frequency-volume chart. Patients were divided into three groups according the severity of nocturia: group 1 consisted of patients with mild (1-2 voids/night), group 2 with moderate (3-4 voids/night) and group 3 with severe nocturia (>4 voids/night). Comparative analysis were performed between groups, p<0.05 was deemed as statistically significant. Results: 68.1%, 64.1% and 8.7% of the patients had nocturnal polyuria, reduced bladder capacity and global polyuria; respectively. 42.7% of the patients had mixed nocturia. 6.1% of the patients did not comply with the afore-mentioned subtypes and defined as isolated nocturia. Regarding the severity of nocturia; 155 (41%) patients had mild, 167 (45%) patients had moderate and 57 (15%) patients had severe nocturia. Increased nocturia severity was related with decreased quality of life; higher age, urinary tract symptom scores, nocturnal urine volume, evening fluid consumption and beta-blocker medication rates. Increased nocturia severity was also associated with higher nocturnal polyuria, global polyuria and reduced bladder capacity rates. Conclusions: Nocturia mechanisms may vary between mild and moderate to severe nocturia groups according to the present study. Nocturia grading with identification of subtypes may help for better standardization of the diagnostic and treatment approaches as well as for the design of future clinical trials.
24 Aug 2020Submitted to International Journal of Clinical Practice
24 Aug 2020Assigned to Editor
24 Aug 2020Submission Checks Completed
31 Aug 2020Reviewer(s) Assigned
07 Sep 2020Review(s) Completed, Editorial Evaluation Pending
11 Sep 2020Editorial Decision: Accept
Mar 2021Published in International Journal of Clinical Practice volume 75 issue 3. 10.1111/ijcp.13722