The mechanical properties and fatigue responses of double-edge-cracked Ti/APC-2 hybrid nano-composite laminates by tensile and cyclic tests were obtained. The double-edged cracks were cut with the crack lengths of 2.0 mm and 3.0 mm symmetrically and anti-symmetrically. The mechanical properties of symmetrically cracked samples are more detrimentally than those of anti-symmetrically counter parts. The greater the cracked angles, the greater the maximum load, however, the results of crack lengths were on the contrary. The fatigue life increased with the crack angle increasing, and also decreased with the crack length increasing. The enhancement of laminates by adding nano-powder did improve the fatigue life and maximum load, but not significantly. It is attributed to the local stress intensity factors at the crack tips mainly dominating the mechanical properties. Hence, the spreading of nano-power at the interface does not effectively strengthen the resistance to fatigue and fracture globally.