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  • +19
  • Leyla Barakat,
  • María José Torres,
  • Elizabeth J. Phillips,
  • Marco Caminati,
  • Yoon-Seok Chang,
  • Davide Caimmi,
  • Mario Sanchez-Borges,
  • Lanny Rosenwasser,
  • Alain Didier,
  • Frédéric De Blay,
  • Jean-François fontaine,
  • Isabelle Bosse,
  • Sébastien lefevre,
  • Cintia Bassani,
  • Maria di Filippo,
  • Ignacio J Ansotegui,
  • Mário Morais-Almeida,
  • Motohiro Ebisawa,
  • Bryan Martin,
  • Bernard Thong,
  • Pascal Demoly,
Leyla Barakat
University Hospital Centre Montpellier

Corresponding Author:[email protected]

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María José Torres
Universidad de Málaga Facultad de Medicina
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Elizabeth J. Phillips
Vanderbilt University School of Medicine
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Marco Caminati
Verona University Hospital
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Yoon-Seok Chang
Seoul National University Bundang Hospital
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Davide Caimmi
Department of respiratory medicine and allergy, Hôpital Arnaud de Villeneuve, CHU Montpellier, Univ Montpellier
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Mario Sanchez-Borges
Centro Medico-Docente La Trinidad
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Lanny Rosenwasser
Children's Mercy Hospitals and Clinics
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Alain Didier
CHU Toulouse
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Frédéric De Blay
University Hospital Strasbourg
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Jean-François fontaine
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Isabelle Bosse
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Sébastien lefevre
Universite de Lorraine
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Cintia Bassani
IMED School of Medicine
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Maria di Filippo
University of Pavia
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Ignacio J Ansotegui
Hospital Quironsalud Bizkaia
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Mário Morais-Almeida
CUF-Descobertas Hospital
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Motohiro Ebisawa
National Hospital Organization, Sagamihara National Hospital
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Bryan Martin
Columbus State University
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Bernard Thong
Tan Tock Seng Hospital
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Pascal Demoly
University Hospital of Montpellier
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Hospital Sírio Libanês
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Background: Allergy is witnessing major advances, in particular with the advent of biological therapies for treating allergic diseases. Given the novelty of these therapeutics, we aimed to explore by a worldwide survey, the prescription and the management of hypersensitivity reactions (HR) of biological agents (BA) in Allergy. Method: We built up an anonymous online questionnaire, sent out by mail and social media and circulated for 40 days. Results: 348 responses were from 59 countries, with a majority from Europe (62.6%). 97% of responders practiced allergy and 48.5%, exclusively so. Allergy was mentioned as a full specialty in 69.5 % of cases. 71% of responders confirmed the right of prescription of BA for allergists in their country and 78.4 % prescribed BA in their clinical practice. Europe included almost all the allergists who did not have the right of prescribing BA (95.5%), specifically France (91%). The most prescribed BA were Anti IgE (78.1%) and anti IL5 (43.9%). The most declared HR to BA were local reactions (74.1%) followed by anaphylaxis like symptoms (6.8%) and delayed exanthemas (5.1%). Desensitization was considered in 18.9% of cases. These HR were reported in 48.8% of cases. Conclusion: Although BA are now a pillar in the treatment of allergic diseases and allergists are familiar with management of HR associated with BA, their prescription is not authorized for allergists in all countries. BA showed to be generally safe but HR, which may be severe, could occur with a lack of consensus on the management.