The Clinical Effect of Bronchoscopic Alveolar Lavage with Acetylcysteine
and Budesonide in the Treatment of Refractory Mycoplasma Pneumonia in
Children
Abstract
【Abstract】Objective To investigate the clinical effect of bronchoscope
alveolar lavage (BAL) combined with different drugs in the treatment of
refractory Mycoplasma pneumoniae pneumonia(RMPP). Methods Eighty-two
patients with RMPP who were admitted to Pediatrics of The First People’s
hospital of Zhengzhou from July 2017 to July 2019 were retrospective
analyzed. All the patients were given BAL. The patients were divided
into three groups according to the different drugs added by BLA, namely
Budesonide group, Ambroxol+budesonide group, and
acetylcysteine+budesonide group. The changes of laboratory examination
indexes, the improvement of pulmonary imaging, the total effective rate
and the occurrence of adverse reactions were analyzed. Results The
laboratory test indexes of the 3 groups were more to improve than that
before treatment, the difference was statistically significant. There
was no significant difference in white blood cell (WBC), C-reactive
protein(CRP) and erythrocyte sedimentation rate (ESR) among the three
groups after treatment. There were significant differences in serum
lactate dehydrogenase (LDH) and serum ferritin (SF) among the three
groups (P<0.05). The rate of pulmonary imaging absorption and
clinical effective rate in acetylcysteine +budesonide group were better
than another two groups (P<0.05) .There were no significant differences
in the incidence of adverse reactions among the three groups
(P>0.05). Conclusions BLA with acetylcysteine+ budesonide
is more effective than another two groups in improving the efficacy of
treatment of children with RMPP, it could promote the absorption of the
opacity, and reduce the inflammatory response of the lungs.