Results of the preparation of biodegradable porous scaffolds using an
original modification of a wet phase inversion method were presented.
Influence of gelatin nano-non-woven as a non-classic pore precursor and
polyvinylpyrrolidone, Pluronic® as classic pore precursors on the
structure of obtained scaffolds was analyzed. It was shown that the
addition of gelatin nano-non-wovens enables the preparation of
scaffolds, which allow for the growth of cells (size, distribution, and
shape of pores). Mechanical properties of the obtained cell scaffolds
were determined. The influence of pore precursors on mass absorption of
scaffolds against isopropanol and plasma was investigated. Interaction
of scaffolds with a T-lymphocyte line (Jurkat) and with fibroblasts
(L929) was investigated. Obtained scaffolds are not cytotoxic and can be
used as implants, e.g. the regeneration of cartilage tissue.