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Medication related jaw osteonecrosis (MRONJ) late onset 3 years after IPILIMUMAB endovenous administration: a possible role of target therapy
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  • Agostino Guida,
  • Francesco Perri,
  • Franco Ionna,
  • Paolo A Ascierto,
  • Antonio Maria Grimaldi
Agostino Guida
INT – IRCCS “Fondazione G. Pascale”, Naples, Italy

Corresponding Author:[email protected]

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Francesco Perri
Istituto Nazionale Tumori IRCCS Fondazione Pascale
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Franco Ionna
INT – IRCCS “Fondazione G. Pascale”, Naples, Italy
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Paolo A Ascierto
INT – IRCCS “Fondazione G. Pascale”, Naples, Italy
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Antonio Maria Grimaldi
INT – IRCCS “Fondazione G. Pascale”, Naples, Italy
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Abstract

Ipilimumab has been associated to medication related jaw osteonecrosis (MRONJ) only two times in literature. A woman underwent therapy with ipilimumab for Metastatic Melanoma in 2015 and she developed MRONJ in 2018. She was successfully treated with medical therapy alone. Vigilance in dental management of these patients is needed.

Peer review status:ACCEPTED

03 Jun 2020Submitted to Clinical Case Reports
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15 Jul 2020Submission Checks Completed
15 Jul 2020Assigned to Editor
19 Jul 2020Reviewer(s) Assigned
27 Jul 2020Review(s) Completed, Editorial Evaluation Pending
07 Aug 2020Editorial Decision: Revise Minor
08 Sep 20201st Revision Received
10 Sep 2020Assigned to Editor
10 Sep 2020Submission Checks Completed
10 Sep 2020Review(s) Completed, Editorial Evaluation Pending
11 Sep 2020Reviewer(s) Assigned
26 Sep 2020Editorial Decision: Revise Minor
28 Sep 20202nd Revision Received
29 Sep 2020Assigned to Editor
29 Sep 2020Submission Checks Completed
29 Sep 2020Review(s) Completed, Editorial Evaluation Pending
05 Oct 2020Editorial Decision: Accept