loading page

Therapeutic drug monitoring of biologic agents in inflammatory bowel disease: limits and improvements.
  • +1
  • Jose María Giráldez-Montero,
  • Jaime González-López,
  • Manuel Campos-Toimil,
  • MJ Lamas
Jose María Giráldez-Montero
Complexo Hospitalario Universitario de Santiago de Compostela

Corresponding Author:[email protected]

Author Profile
Jaime González-López
Complexo Hospitalario Universitario de Santiago de Compostela
Author Profile
Manuel Campos-Toimil
Universidade de Santiago de Compostela Facultad de Farmacia
Author Profile
MJ Lamas
Health Research Institute of Santigao de Compostela
Author Profile


Since the publication of the American Gastroenterological Association’s (AGA) recommendations in 2017, there have been no significant changes in the biological monitoring recommendations. Lack of evidence on proactive therapeutic drug monitoring (pTDM) over the reactive therapeutic drug monitoring (rTDM) and the absence of recommendations on the individualized dosage methods have been limiting. The aims of this review were to identify updates on TDM strategies and in individualized dosing methods. For the analysis of the TDM strategies and individualized dosing method, a search was carried out in PubMed and Cochrane Central. In TDM case, since 2017. A total of 263 publications were found. Only 7 related to pTDM. Two of them were clinical trials and one systematic review. Of the 8 studies analyzed, 7 found benefit from pTDM over rTDM and one found no difference. Only one study was prospective. Regarding the individualized dosing method, 229 results were found. Population pharmacokinetics was the most widely used technique to explore and develop individual dosage models. It has been used to analyze the influence of factors on drug concentrations (serum albumin, weight… etc. We have not found major changes in TDM strategies. The available evidence is limited and of low quality. Retrospective designs and low power of the studies are the main problems. Population pharmacokinetics methods are the most widely used. But are more used to identify factors that affect drug concentrations than for dosage individualization.
03 Jul 2020Submitted to British Journal of Clinical Pharmacology
07 Jul 2020Submission Checks Completed
07 Jul 2020Assigned to Editor
08 Jul 2020Reviewer(s) Assigned
20 Aug 2020Review(s) Completed, Editorial Evaluation Pending
21 Aug 2020Editorial Decision: Revise Major
24 Sep 20201st Revision Received
25 Sep 2020Assigned to Editor
25 Sep 2020Submission Checks Completed
25 Sep 2020Review(s) Completed, Editorial Evaluation Pending
28 Sep 2020Reviewer(s) Assigned
27 Oct 2020Editorial Decision: Revise Minor
28 Oct 20202nd Revision Received
29 Oct 2020Assigned to Editor
29 Oct 2020Submission Checks Completed
29 Oct 2020Review(s) Completed, Editorial Evaluation Pending
08 Nov 2020Editorial Decision: Accept