Antiadherent Immune Response (AAIR) against serotype 026: EPEC (Enteropathogenic (invasive) Escherichia coli) a fatal diarrhoea was successful in Balb/c mice experiment by the author. IS(Insertion Sequence) represented by IS1,IS2,IS3,-……IS10 flanking transpons ( Tn)”IS-TN-IS” and its illegitimate recombination was also studied curiously by the author to observe their spontaneous jumping, illegitimate recombination among DNA, chromosome and plasmids in Escherichia coli. Considering the fatality rate of corona as pandemic globally, the author has attempted to realise the possible application of AAIR and IS-Tn-IS mixed hybrid concept, in designing vaccine against corona, to prevent corona virus not to adhere in trachea and lung cells, to bring healthy life to mankind. IS-Tn-IS was studied in Maize by Barbara Mc Clintock, USA, Peter Starlinger and H.Saedler, Germany studied the same in bacteria.. In this paper the author describes the possible AAIR vaccine against corona. A mixture of combine strategy corona vaccine with IS-Tn-IS gene expression.