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Malignant Salivary Gland Tumours - a single centre experience
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  • Akshat Malik,
  • Yadsan Devabalan,
  • Jonathan Bernstein,
  • Zaid Awad,
  • Dorothy Gujral,
  • Sarah Partridge,
  • Gitta Madani,
  • Peter Clarke,
  • Justin Weir,
  • Alasdair Mace
Akshat Malik
Charing Cross Hospital

Corresponding Author:[email protected]

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Yadsan Devabalan
Charing Cross Hospital
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Jonathan Bernstein
Imperial College Healthcare NHS Trust
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Zaid Awad
Imperial College
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Dorothy Gujral
Imperial College Healthcare NHS Trust
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Sarah Partridge
Imperial College Healthcare NHS Trust
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Gitta Madani
Imperial College Healthcare NHS Trust
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Peter Clarke
Imperial College Healthcare NHS Trust
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Justin Weir
Imperial College Healthcare NHS Trust
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Alasdair Mace
Royal Free Hospital
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Objectives: Salivary gland malignancies are an uncommon and heterogeneous group of cancers. We report our experience of clinicopathological variables that affect survival in patients treated by curative intent with surgery at a UK institution over a period of 15 years. Design: Retrospective cohort study Setting: Single centre study Participants We included 108 patients with malignant salivary gland tumours treated by curative intent with surgery from 2004 to 2019. Main outcome measures: The association between clinicopathological factors and their impact on overall survival (OS) and disease-free survival (DFS). Results: 77 (71.3%) presented with early pT classification and 81 (75%) of were node-negative. The parotid was the commonest site of malignancy (86, 79.6%). Perineural invasion (PNI) was present in 40 (37%) and lymphovascular invasion (LVI) was present in 20 (18.5%). 63 (58.3%) underwent adjuvant therapy. Median follow up was 36 months. Five-year OS and DFS were 81.7% and 71%. Age 50, pT classification 3-4, high tumour grade, PNI, and advanced TNM stage were all associated with worse OS and DFS, and LVI with worse DFS. There was no survival difference between a close (1-<5 mm) or negative (≥5 mm) resection margin. Conclusions: Age >50 years, advanced TNM stage, PNI and LVI are predictors of poor DFS. There was no difference in OS or DFS between patients with negative and close resection margins, indicating that close margins may be adequate for maintaining good oncologic outcomes in this group of patients.
06 Jun 2020Submitted to Clinical Otolaryngology
10 Jun 2020Submission Checks Completed
10 Jun 2020Assigned to Editor
14 Jun 2020Editorial Decision: Revise Minor
03 Aug 20201st Revision Received
14 Aug 2020Assigned to Editor
14 Aug 2020Submission Checks Completed
30 Oct 2020Reviewer(s) Assigned
01 Mar 2021Review(s) Completed, Editorial Evaluation Pending
01 Mar 2021Editorial Decision: Revise Minor
14 Mar 20212nd Revision Received
15 Mar 2021Submission Checks Completed
15 Mar 2021Assigned to Editor
19 Mar 2021Reviewer(s) Assigned
08 Jul 2021Editorial Decision: Accept