Isolated Optic Nerve Leukemic Relapse Diagnosed via Fine Needle
Aspiration Biopsy and Transconjunctival Biopsy
Pre-B cell acute lymphoblastic leukemia (ALL) is a hematologic
malignancy that arises from overproduction of immature lymphoid cells.
ALL has a propensity for recurring in the bone marrow and/or
extramedullary sites following complete remission. We present the case
of a young male with a history of pre-B cell ALL who presented with
leukemic recurrence isolated to the optic nerve. Transvitreal fine
needle aspiration biopsy followed by transconjunctival optic nerve
biopsy confirmed the diagnosis of ALL relapse and should be considered
helpful diagnostic tools in the setting of suspected optic nerve
malignancy with otherwise negative workup.