Research into the effect of proton pump inhibitors on lungs and
Backround and Purpose. Proton pump inhibitors (PPI) are the most
commonly used medication in the world. They are prescribed as an
effective treatment choice for gastrointestinal system diseases linked
to hyperacidity, especially. Many publications in recent times have
reported significant side effects. However, there are insufficient
studies about the topic of the mechanism for these side effects.
Experimental Approach. Rats were divided into 3 groups of control, a
group administered H2 receptor blockers and a group administered PPI (n:
8). Medications were administered for 30 days intraperitoneal. After 30
days, rats were euthanized and lung tissue was obtained. Lung were
stained for immunohistochemical Catalase, Superoxide Dismutase,
Glutation Peroxidase, Myeloperoxidase and toluidine blue and
investigated with a light microscope. Transmission Electron Microscopy
(TEM) was used to investigate lung tissues and neutrophil leukocytes.
Additionally, lung tissue had biochemical H2O2 levels researched. Key
Results. H2O2 amounts, produced by lysosomes with important duties for
neutrophil functions in lung tissues, were found to be statistically
significantly reduced in the group administered PPI. Results of
investigations of preparates obtained with immunohistochemical staining
observed increases in antioxidant amounts in the PPI group.
Investigation with TEM identified more inflammation findings in the lung
tissue from the group administered PPI compared to the control group and
the group administered H2 receptors. Conclusion and Implications. In
conclusion, we identified long-term PPI use disrupts neutrophil
leukocyte functions in lung. All clinicians should be much more careful
about PPI use.