loading page

Surface engineering of biomaterials: optimizing interactions between biomaterials and host tissues and organs
  • Ziqian Liu,
  • Xiaoling Liu,
  • Seeram Ramakrishna
Ziqian Liu
University of Nottingham Ningbo China Faculty of Science and Engineering

Corresponding Author:[email protected]

Author Profile
Xiaoling Liu
University of Nottingham - Ningbo China
Author Profile
Seeram Ramakrishna
National University of Singapore
Author Profile


Interfaces between biomaterials and living system are critical in regulating their interactions. Poor biocontact properties always limited the performance of biomaterials in biological environment. Surface engineering aims to control the interface interaction to further enhance the desired behavior of biomaterials. Upon implantation of biomaterials into the biological environment, a series of host responses are initiated. Non-specific protein adsorption on biomaterials is the essential stage of all biological reactions that associated with implants failure, device-related infections and blood-coagulation. In this review, we first focused on surface modification techniques to eliminate protein adsorption by emphasizing PEGylation of both macroscopic surface and nanoparticle system. Next, recent developments in surface engineering of biomaterials to optimize interactions between biomaterials and specific host tissue and organs are discussed. Optimizing the biocontact property of blood-contact devices can improve their hemocompatibility and maintain vascular homeostasis. Surface modifications of orthopedic and dental implants confer improved osteointegration and tribology performance. Controlling the surface chemistry and topography, and immobilizing biomolecules can aid the expansion and direct the differentiation of stem cells.
25 May 2020Submitted to Biotechnology Journal
25 May 2020Submission Checks Completed
25 May 2020Assigned to Editor
26 May 2020Reviewer(s) Assigned
23 Jun 2020Editorial Decision: Revise Major
20 Jul 20201st Revision Received
21 Jul 2020Submission Checks Completed
21 Jul 2020Assigned to Editor
21 Jul 2020Reviewer(s) Assigned
28 Aug 2020Editorial Decision: Revise Major
23 Nov 20202nd Revision Received
23 Nov 2020Assigned to Editor
23 Nov 2020Submission Checks Completed
23 Nov 2020Reviewer(s) Assigned
15 Feb 2021Editorial Decision: Revise Minor
19 Feb 20213rd Revision Received
22 Feb 2021Submission Checks Completed
22 Feb 2021Assigned to Editor
22 Feb 2021Reviewer(s) Assigned
08 Mar 2021Editorial Decision: Revise Minor
11 Mar 20214th Revision Received
11 Mar 2021Submission Checks Completed
11 Mar 2021Assigned to Editor
16 Mar 2021Editorial Decision: Revise Minor
23 Mar 20215th Revision Received
23 Mar 2021Submission Checks Completed
23 Mar 2021Assigned to Editor
30 Mar 2021Editorial Decision: Accept