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Clinical features of asthma with comorbid bronchiectasis: a systematic review and meta-analysis.
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  • shiqi zhang,
  • xiaofeng xiong,
  • zuohong wu,
  • tingting huang,
  • deyun cheng
shiqi zhang

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xiaofeng xiong
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zuohong wu
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tingting huang
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deyun cheng
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Objective: This meta-analysis aimed to systematically estimate the prevalence of comorbid bronchiectasis in patients with asthma and to summarize its clinical impact. Data sources: Embase, PubMed, and Cochrane Library electronic databases were searched to identify relevant studies published from inception until March 2020. Study Selection: Studies were included if bronchiectasis was identified by high-resolution computed tomography. Outcomes included prevalence of bronchiectasis and its association with demographic characteristics and indicators of asthma severity, including results of lung function tests and number of exacerbations. Results: Five observational studies with 839 patients were included. Overall, the mean prevalence of bronchiectasis in patients with asthma was 36.6% (307/839). Patients with comorbid bronchiectasis had lower forced expiratory volume (FEV1)/forced vital capacity (FVC) (MD: -2.71; 95% CI: -3.72 to -1.69) and more frequent exacerbations (MD: 0.68; 95% CI: 0.03 to 1.33) than those with asthma alone, there was no significant difference of sex, duration of asthma and serum levels of immunoglobulin(Ig)Es between asthmatic patients with or without bronchiectasis. Conclusion: The presence of bronchiectasis in patients with asthma was associated with greater asthma severity. There are important therapeutic implications of identifying bronchiectasis in asthmatic patients.
29 Jan 2021Published in Medicine volume 100 issue 4 on pages e23858. 10.1097/MD.0000000000023858