Genome analysis of Getah virus (GETV) isolated from and contaminated in
a live swine vaccine: The commercial live vaccines might be a potential
route for GETV transmission
Abstract
GETV cause fetus death and reproductive disorders in pigs. In this
study, a GETV strain, named GETV-V1, was isolated from a commercial
modified live vaccine (MLV) against porcine reproductive and respiratory
syndrome virus (PRRSV), which is widely used on pigs in China. Further
results showed that nine batches of MLV vaccine (three batches per year)
from the same manufacturer between 2015 and 2017 were all positive for
GETV. We then further characterized the GETV-V1 strain and performed
phylogenetic analysis, revealing that the GETV strains circulating in
China are genetically diverse and providing a potential platform for
evolution. Therefore, this research firstly reported the contamination
of GETV in live attenuated PRRS vaccines in China, implying that
monitoring of exogenous virus in live vaccines for pigs needs to be
improved.