Peroxiredoxins are involved in the pathogenesis of multiple sclerosis
and neuromyelitis optica spectrum disorder
Peroxiredoxins (PRXs) are intracellular antioxidative enzymes but work
as inflammatory amplifiers under the extracellular condition. To date,
the function of PRXs in the pathogenesis of multiple sclerosis (MS) and
neuromyelitis optica spectrum disorder (NMOSD) is not fully understood.
The aim of this study was to investigate whether PRXs play a role in the
pathogenesis of MS and NMOSD. We analyzed levels of PRXs (PRX1, PRX5,
and PRX6) in the CSF and serum of 16 patients with MS, 16 patients with
NMOSD, and 15 patients with other neurological disorders (ONDs). We
identified potential correlations between significantly elevated PRXs
levels and the clinical variables in patients with MS and NMOSD.
Additionally, pathological analyses of PRXs (PRX1-6) in the central
nervous system were performed using the experimental autoimmune
encephalomyelitis (EAE), animal model of MS. We found that serum levels
of PRX5 and PRX6 in patients with MS and NMOSD were higher compared with
those in patients with ONDs (p < 0.05). Furthermore, high
levels of PRX5 and PRX6 were partly associated with blood–brain barrier
dysfunction and disease duration in NMOSD patients. No significant
elevation was found in CSF PRXs levels of MS and NMOSD. Spinal cords
from EAE mice showed remarkable PRX5 staining, especially in CD45+
infiltrating cells. In conclusion, PRX5 and PRX6 may play a role in the
pathogeneses of MS and NMOSD.