The association of PCOS and hypertensive disorders of pregnancy -a
community based approach
Abstract
OBJECTIVE To investigate the prevalence of hypertensive disorders of
pregnancy (HDP), and the roles of polycystic ovary syndrome (PCOS),
obesity, weight gain (WG) and hyperandrogenaemia in the development of
HDP by age 46. DESIGN prospective population-based cohort. Setting and
population The Northern Finland Birth Cohort 1966 (NFBC1966) METHODS
Follow-up at ages 14, 31 and 46, including women with (n=408) and
without (n=3373) HDP. HDP was combined from the questionnaire data at
age 46, hospital discharge records and Finnish Medical Birth Registers.
Women with both oligo-amenorrhea and hirsutism at age 31 and/or with
PCOS diagnosis by age 46 (self-reported PCOS, srPCOS, n=279) were
compared with women without symptoms or PCOS diagnosis (n=1577). Main
outcome measures Association of PCOS and WG through life with HDP
RESULTS Women with srPCOS had an increased HDP risk ([OR]=1.56
[95%CI:1.03-2.37]), but the association disappeared after BMI
adjusting at age 31. Increase of BMI from age 14 to 31 was significantly
greater in srPCOS (median [interquartile
range]:5.94kg/m2[3.69;11.1], p<0.001) and non-PCOS
(4.89kg/m2[3.21;7.57], p<0.001) women with HDP and in
srPCOS women without HDP (4.59kg/m2[2.40;7.54], p=0.009) compared to
non-PCOS without HDP. Among women with srPCOS, BMI increase was greater
in women with than without HDP (5.94kg/m2 [3.69;11.1] vs
4.59kg/m2[2.40;7.54], p=0.015). Hyperandrogenaemia at 31 or 46 did
not associate with HDP (OR=1.44[95%CI: 0.98-2.11]). CONCLUSION
Obesity and weight gain from adolescence to age 46, but not srPCOS or
hyperandrogenaemia, were associated with an increased risk of HDP.