Review Article Time to change theory; Medical Leech from a molecular
medicine perspective Leech salivary proteins playing a potential role in
medicine
Abstract
Followed by developing modern medicine, leeches did not have extensive
use as before, however, in the late 19th century, they were still used
in most countries all over the world. Thus far, leeches were utilized in
treating various diseases like skin disorders, arthritis, and cancer. In
Egypt, using leeches for treatment dates back to early 1500 BC. A
medical leech’s salivary glands involve over 100 bioactive materials and
the salivary gland secretion contains bacteriostatic, analgesic, and
anti-coagulation influences; with resolving activity, it causes
microcirculation disorders elimination, restoring the hurt vascular
permeability of organs and tissues, removing hypoxia, decreasing blood
pressure, increasing immune system activity, and detoxifying the
organism by antioxidant paths. The current work reviews the innovative
treatment with medical leech especially proteins in leech saliva with
high potential in medicine. The results showed that by the virtue of
salivary gland secretions which are proteinaceous enzymes, leech acts on
various diseases such as venous congestion in reconstructive and plastic
surgery, osteoarthritis, cardiovascular diseases caused by blood
coagulation disorders, skin disorders, migraine headache, diabetic foot
ulcers, priapism, macroglossia, cancer complications, wounds and many
other. To confirm the potential therapeutic impacts of leech treatment,
more studies are required in more extensive areas with more exact
methodologies.