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Science AMA Series: We are Drs. Brenda Moore and Todd Golde, neuroscientists at the University of Florida. Our findings reveal the potential for a drug therapy to be developed that could one day stop the progression of Alzheimer’s. Ask Us Anything!
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Hello Reddit, I am Brenda Moore, Ph.D., a neuroscientist in Dr. Todd Golde’s lab at the University of Florida. We conduct disease-oriented research with a focus on Alzheimer’s and other neurodegenerative diseases. And I am Todd Golde, M.D., Ph.D., director of the Evelyn F. and William L. McKnight Brain Institute at UF, where I oversee, champion and facilitate neuroscience and neuromedicine research programs across our campus. I am also director of the 1Florida Alzheimer’s Disease Research Center consortium of institutions. We recently published a study featured on the cover of the Journal of Experimental Medicine titled Short Aβ peptides attenuate Aβ42 toxicity in vivo. Our research shows that short Abeta peptides were not toxic in two animal models — a mouse and a fruit fly — and in fact were protective from the toxic effects of Abeta 42. The accumulation of Abeta 42 in the brain is widely recognized as key in promoting Alzheimer’s disease. Our findings hold the potential for a drug therapy that could go beyond treating the symptoms of Alzheimer’s and target the disease’s progression. To read our paper and news release, visit http://bit.ly/2nocJPI. We will answer your questions at 1 pm EST ­— Ask Us Anything! Thank you everyone for your great questions, we enjoyed answering them!