Science AMA Series: We are Drs. Brenda Moore and Todd Golde,
neuroscientists at the University of Florida. Our findings reveal the
potential for a drug therapy to be developed that could one day stop the
progression of Alzheimer’s. Ask Us Anything!
Hello Reddit, I am Brenda Moore, Ph.D., a neuroscientist in Dr. Todd
Golde’s lab at the University of Florida. We conduct disease-oriented
research with a focus on Alzheimer’s and other neurodegenerative
diseases. And I am Todd Golde, M.D., Ph.D., director of the Evelyn F.
and William L. McKnight Brain Institute at UF, where I oversee, champion
and facilitate neuroscience and neuromedicine research programs across
our campus. I am also director of the 1Florida Alzheimer’s Disease
Research Center consortium of institutions. We recently published a
study featured on the cover of the Journal of Experimental Medicine
titled Short Aβ peptides attenuate Aβ42 toxicity in vivo. Our research
shows that short Abeta peptides were not toxic in two animal models —
a mouse and a fruit fly — and in fact were protective from the toxic
effects of Abeta 42. The accumulation of Abeta 42 in the brain is widely
recognized as key in promoting Alzheimer’s disease. Our findings hold
the potential for a drug therapy that could go beyond treating the
symptoms of Alzheimer’s and target the disease’s progression. To read
our paper and news release, visit http://bit.ly/2nocJPI. We will answer
your questions at 1 pm EST — Ask Us Anything! Thank you everyone for
your great questions, we enjoyed answering them!