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PLOS Science Wednesday: Hi reddit, we’re Marinho and Leandro and we applied math models to explore the brain regions that contribute most to seizures to help neurosurgeons perform more targeted surgeries for epilepsy patients – Ask Us Anything!
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Hi Reddit, My name is Marinho Lopes and I am a Research Fellow at the University of Exeter. And I’m Leandro Junges and I am a Research Fellow at the EPSRC centre for predictive modelling in healthcare at the University of Exeter. Our research focuses on the mechanisms of seizure emergence and on mathematical models to quantitatively predict whose brains regions are most responsible for seizure generation. Our group recently published a paper titled “An optimal strategy for epilepsy surgery: Disruption of the rich-club?” in PLOS Computational Biology. We used statistical methods to determine how different regions were connected from the electrical recordings of the brain. We then applied advanced mathematical modelling to study which regions of the brain contribute most greatly to generating seizures and whether their removal would result in the brain being seizure-free. The idea being that if brain surgeons targeted these regions the outcome of surgery would be enhanced. We will be answering your questions at 1pm ET– Ask Us Anything! Don’t forget to follow our group on Twitter @CBMA_UoE.