loading page

PLOS Science Wednesday: Hi Reddit, I’m Zhengquan Yu, here to talk about my recent PLOS Genetics paper that has identified the key role of a microRNA in hair loss. I’m joined by Maksim Plikus, who studi
  • PLOSScienceWednesday ,
  • r/Science AMAs

Corresponding Author:[email protected]

Author Profile
r/Science AMAs
Author Profile


Hi Reddit, My name is Zhengquan Yu and I am an associate professor at the China Agricultural University. Joining me in this AMA is my colleague, Maksim Plikus from the University of California, Irvine, who studies the principles and mechanisms of adult stem cell regulation using hair follicle as the primary model system. My research focuses on regulatory network of somatic stem cells in hair follicle and mammary gland. We recently published a research article titled Post-transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22 in PLOS Genetics. We describe an essential role for a highly conserved microRNA, miR-22, in regulating the regression of mouse hair follicles. We found that increasing miR-22 results in hair loss in mice due to the premature regression of follicles, and that silencing of keratin-mediated hair shaft assembly by miR-22 is a prerequisite for follicle regression. There are hundreds of microRNAs expressed in hair follicles, but most of them are not well studied. This paper highlights the importance of determining the combinatorial effects of the microRNA regulatory network in hair cycling and provides new insights into the mechanism of premature hair follicle regression in understanding the pathology of hair loss. We will be answering your questions at 1pm ET (10 am PT, 5 pm UTC), Ask Us Anything!