What HeLa Cells Are You Using?
AbstractThe HeLa cell line, named after the patient Henrietta Lacks, was one the
first human cell lines to be used for tissue culture. In the decades
since its origin, it has become a feature in labs across the world.
Despite its longevity, repeated detection of most HeLa marker
chromosomes have lead the scientific community to view HeLa as a stable
cell line and its corresponding findings to be reproducible. However, to
date no investigation has examined other meaningful aspects of HeLa's
genomic variability, such has whether HeLa's modal chromosome number
remains constant. Considering the importance of a cell line's karyotype
with respect to reproducibility, I sought to examine the stability of
HeLa's karyotype by examining HeLa's modal chromosome number as reported
in the literature.