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Intelligence GWAS hits: Selection signal or population structure? A test of the null hypothesis
  • Davide Piffer
Davide Piffer

Corresponding Author:[email protected]

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An index of population structure (Fst) is used to test the null hypothesis that the genetic factor extracted from GWAS hits represents differences between populations due to migrations and drift. Employing the 1000 Genomes data, a regression of average IQ distances on the general intelligence genetic factor and Fst distances shows that the former is the only significant predictor of IQ distances(Beta= 0.82), whereas the population structure has no independent predictive power (Beta=-0.05). This result suggests that the null hypothesis can be rejected.