Two-phase flow of CO₂/brine in porous media is critical to the capacity and safety of carbon sequestration into the brine aquifer. In order to provide valuable information and important theoretical basis for site selection and CO₂ injection, the microscopic visualization technology was employed in this study to conduct displacement experiments of CO₂/brine at the pore scale. Four micromodels with different sizes and structures, five injection rates of CO₂ and six salinities of brine were used to study the effects of micromodel’s structure and displacement pattern on two-phase flow. Several parameters including the differential pressure, contact angle, permeability, velocity field and force field were obtained by experimental measurement, image post-processing and theoretical analysis, and then these parameters’ variation was investigated. Phenomena such as thin film, corner flow and Haines jump were also found during the displacement. Although brine could be completely displaced by CO₂ in the capillary duct, the backflow of wetting phase would occur at low injection rate. Phenomena different from the theoretical analysis also occurred in pore doublet models: some brine was residual in the homogeneous pore doublet model at low injection rate, while the heterogeneous pore doublet model was fully occupied by CO₂ at high injection rate. These phenomena are very useful for two-phase flow, and multiple factors need to be comprehensively considered to determine the operating conditions of CO₂ storage into the brine aquifer.