In this post, we assess Authorea's compliance to FAIR principles (https://www.go-fair.org/fair-principles/), i.e. how the repository observes principles of machine-actionability: to find, access, interoperate, and reuse data with none or minimal human intervention

We present a Bayesian approach for modeling a time series for a cumulative record that takes the form of the maximum or minimum of a sequence of attempts, in the absence of data for the underlying attempts. We discuss the derivation of the likelihood function, sampling of the posterior via PyMC3, and forecasting the distribution of future records.

In the paper the theoretical basis of pumped-storage power plant operation is presented. Working conditions of hydraulic machines in these kinds of objects are described and examples are given. The Czech research results as well as German theoretical analyses on the topic of water energy storage in underground mines are characterized. The conditions for building pumped-storage power plant in Polish underground coal mines, including liquidated ones, are determined. Analysis of parallel operation of multistage centrifugal pumps, dedicated to the mine drainage system, manufactured and operated commonly in Poland is presented. The main dimensions calculations of two multistage centrifugal pumps (power of 10 MW and 25 MW), dedicated for selected parameters, are presented.

BACKGROUND Hemophagocytic lymphohistiocytosis (HLH) is a severe and potentially deadly condition associated with extensive inflammation and immune activation. Cytokine adsorption may serve as a supportive treatment that can stabilize organ function in affected patients by reducing their circulating cytokines levels. To date, no descriptions of clinical experiences associated with the use of HA330-II column hemoadsorption for the treatment of HLH children have been published. CASE SUMMARYWe describe a 11-year-old children with Epstein-Barr virus (EBV)-associated HLH combined with liver failure. She underwent HA330-II column hemoadsorption and chemotherapy, and developed a decreased inflammatory cytokines including interleukin (IL)-6, IL-8, IL-10, and interferon (IFN)-γ. The patient’ condition and laboratory parameters gradually improved.CONCLUSIONHemoadsorption may play an important role in eliminating cytokines storm in children with Hemophagocytic lymphohistiocytosis combined with liver failure and consequent multiple organ failure.  Keywords: hemoadsorption; HA330-II column; Hemophagocytic lymphohistiocytosis; Pediatric; Liver failure; Case report

A Double inverter powered induction motor with open stator winding has few benefits, including excessive error forbearance functionality, great flexibility and lesser rating of dc input voltage etc. For this Configuration, two types of Modules can implement they are Non-isolated DC link and Isolated DC link. In these two, Non-isolated DC link is a good choice due to effective DC-link utilization and ruggedness, which is very beneficial in many applications. However, this module produces more zero sequence currents (Z-SC) by means of common mode (CMMD) voltage, which flows through Dc bus. The circulation of Z-SC must as little as feasible since it merely does rise the amplitude of currents in all phases. High ripple frequency of currents and torque, In addition resulting extra loss, which not alone reduces the efficiency, but loading ability and quickens the aging of drive. The triplen harmonics can denote meticulously as harmonics with integer of three times the frequency at fundamental, when they are in Phase in all Phases forms the Z-SC. In this paper, a novel SHE method is chosen to target triplen harmonics in Single DC Source Module (Non- isolated) and holding preferred fundamental quantity, which aids in improving the torque handling ability of the motor. In addition, the investigation of dual inverter fed OEW-IM with both common DC source as well as separate DC sources also explored by SHE for different number of switching angles and variable Modulation Index (MI) towards the torque ripples and Z-SC reduction are given. The foremost challenge related with SHE method is that resolving a set of higher order nonlinear equations with number of variables. A Multi-objective GA method provided for that challenge which effects the reduction in Z-SC so that torque ripples will be minimised. Moreover, the novel SHE method reduces more number of harmonics than the conventional SHE, which further decreases TH-D with decent fundamental quantity. For validation, the essential mathematical formulations and simulation results presented.

Document history

Introducción La fuerza elástica es la generada por un resorte al ser comprimido o estirado respecto de su longitud natural. Es una fuerza restitutiva, es decir que se opone a la fuerza externa que la deforma. Esta fuerza depende solamente de cuan desplazado se encuentre el resorte de su longitud natural (Δx) y de una constante elástica que es propia del resorte (k). Esto puede verse en la siguiente ecuación:\(F_e=-kΔx\)                                                            (Ecuación 1)  Siendo Δx= x-L0, donde x es la posición final y Lo la longitud natural del resorte  Además, se puede plantear la ecuación de Newton de un cuerpo que se encuentra suspendido verticalmente de un resorte. las fuerzas que actúan son:\(ma=mg\ +\ F_e\)                                                   (Ecuación 2)  Pero al encontrarse en equilibrio la aceleración es 0, por lo tanto:

 1. ¿Como me manejo con el mate (termo, yerba, bizcochitos salados, etc.) en el laboratorio?No me manejo. Todo lo que sea comestible se deja afuera del Laboratorio.2. Se me cae un líquido de un experimento. ¿Le pido al pañolero un paño (¡cuac!) para secarle?No. Se debe proceder según las Normas de Seguridad especificas para esa sustancia.3. En las “Reglas básicas . . . ” sección II bajo el título “De incendios” punto 7 se indica que debe evacuarse por la ruta designada. ¿Cúal es esa ruta partiendo desde donde estás ahora?Por el pasillo hacia la puerta de salida del Laboratorio4. As ́ı como “lo que mata es la humedad”, ¿qué es “lo peligroso”? ¿La “alta tensión” (diferencia de potencial)? ¿O una “alta” corriente? ¿Cuanta?La alta tensión es lo peligroso para el cuerpo.  Magnitudes mayores a 30 V pueden ocasionar daños o la muerte. 5. En las “Normas de seguridad” en su sección “La corriente eléctrica...” en su última subsección (“Consideraciones . . . ”) se insiste en “Controlar la calidad de la tierra de su circuito antes de conectarlo” ¿Quées en particular lo que tengo que “controlar”? ¿Como me protege “la tierra”? Se debe controlar que los cables estén correctamente conectados. Con una conexión a tierra, evitamos que la corriente eléctrica nos alcance con una magnitud peligrosa para el cuerpo.

Resultados:Media (Tn) =   1.129 sDesvío estándar (DE) = 0.130 sDesvío de medias (DEm) =0.019 sN óptimo =   168.572 De estos datos se desprende el siguiente error estadísticoEE = 0.021 sNuestro resultado final arroja un T igual a T=  (1.129 ± 0.021) s  

 Cada grupo debe volcar sus 10 mediciones en el formato de array de numpy para poder intercambiar datos. g1_masa =  np.array([1.26,3.80,0.74,0.17,0.20,1.67,0.14,0.5,0.19,0.4])g1_largo = np.array([9.52,34.45,11.95,3.83,3.89,9.08,4.47,9.66,4.14,5.43])g1_ancho = np.array([4.74,5.53,2.61,3.66,3.96,6.41,1.70,7.60,3.70,4.16])g1_area = np.array([29.03,53.98,16.68,7.75,8.70,40.08,6.03,48.31,8.60,16.21])a=0.65448274Error de a=0.038667415299g2_masa =  np.array([0.39,0.36,0.48,0.85,0.83,0.06,1.45,0.15,0.30,3.77])g2_largo = np.array([9.81,6.85,10.54,6.47,10.51,4.73,16.34,4.74,5.06,21.76])g2_ancho = np.array([4.59,3.48,8.51,7.86,6.63,2.52,12.44,2.23,2.80,9.28])g2_area = np.array([25.67,13.79,51.23,37.93,44.23,7.47,28.02,7.13,9.59,125.87])A = 0.70955591B = 3.67875871error de A = 0.136741154793g35_masa =  np.array([0.62,0.27,0.45,0.04,0.70,0.39,0.27,1.21,1.20,2.05])g35_largo = np.array([5.84,6.11,6.07,1.00,10.80,7.31,4.63,13.55,13.06,2.80])g35_ancho = np.array([2.15,3.90,4.02,0.88,9.28,3.97,5.42,7.12,6.39,4.28])g35_area = np.array([7.83,16.50,18.26,0.64,71.46,18.44,16.19,55.91,52.24,9.20])A=0.89551635 error de A=0.296844306386B= 3.40431993

Over the past 50 years conservation genetics has developed a substantive toolbox to inform species management. One of the most long-standing tools available to manage genetics - the pedigree - has been widely used to characterize diversity and maximize evolutionary potential in threatened populations. Now, with the ability to use high throughput sequencing (HTS) to estimate relatedness, inbreeding, and genome-wide functional diversity, some have asked whether it is warranted for conservation biologists to continue collecting and collating pedigrees for species management. In this perspective, we argue that pedigrees remain a relevant tool, and when combined with genomic data, create an invaluable resource for conservation genomic management. Genomic data can address pedigree pitfalls (e.g., founder relatedness, missing data, uncertainty), and in return robust pedigrees allow for more nuanced research design, including well-informed sampling strategies and quantitative analyses (e.g., heritability, linkage) to better inform genomic inquiry. We further contend that building and maintaining pedigrees provides an opportunity to strengthen trusted relationships among conservation researchers, practitioners, Indigenous Peoples, and local communities. Keywords: conservation genomics, quantitative genetics, pedigree, kinship,ex situ , in situ

Best Piano Bench 2019- Leading 10 Critiques & Buying Guide Buying a piano can be thrilling yet tiring within the same time. Never you concur? When purchasing a piano, persons center on accessories like headphones, stands, and pedals. Having said that, extremely couple of people young and old have a look at the bench they’ll sit on over the limitless hours of observe. Although, comfort and ease establishes how substantially time you will devote at your piano without having your back aching. For this reason, it is crucial that you just decide upon the Best Piano Benches. But never fret, immediately following reading this write-up with regard to the best piano benches, you are convinced to create the right decision when procuring one! Even when instruments and many other add-ons which include pedals, headphones and stands get substantial consideration for performance, handful of everyday people look at the site that their rear stop will occupy on these limitless several hours of follow. Some even see it being an unneeded added cost and as a rule go for the cheapest option, hoping the shop will throw it in the offer. Remember which the subliminal messages of consolation vs distress can be an incredible finding out aspect into how significantly time you'll hope to invest at your instrument. With that in mind, the choice of seating at your instrument is as important if not more so, than your option of instrument and investing a little excess in this article might have a long-term effect on the satisfaction of your instrument. So in conditions of benches, what on earth is it that one really should be in need of. Prior to I checklist some options here would be the important factors to explore. 1. A hard seat vs a delicate padded seat. This can be extremely a subject of flavor and can rely on normal padding already to choose from to each individual. Hard seats may become seriously unpleasant just after time specifically as soon as you very often absence good posture and muscle support. Padded seats can are more likely to maximize whole body temperature even though and bring about excess perspiration (also not more comfortable). Individually I favour a hard seat that also facilitates one to move a little simpler if needed. 2. Adjustable vs. non-adjustable seats. If you decide to operate a training studio and distinctive most people will use the bench an adjustable bench is definitely a good financial commitment. For anybody who is particular about selecting just that right place you are going to take pleasure in getting the option to adjust. If not should the bench is just intending to be employed by you by all suggests use a good non-adjustable range. 3. Would you will need a broader bench (for duets or simply appearance on your instrument) or will a single seater suffice? 4. Would you prefer a bench that gives a compartment for storing sheet music? So scan our best digital piano benches review that lists 8 options we expect satisfy the necessities of getting contemplated an awful lot a lot better than a ‘bum deal’  https://sensepot.com/pros-cons-big-breasts/

 In tropical forests, the sustainable management of timber stocks relies to a large extent on the accurate estimates of commercial volumes. In the context of high degradation of  West-African forests, non-destructive methods by using volume equations to make timber stock estimations. Nevertheless, the use of inaccurate equations has often led decision makers to misjudge the real potential of west-African managed forests and increase the threat to sustainable timber production. So, this study aims to improve the accuracy of volume estimations of standing tree in both natural forest-stands and plantations. We consider bole volume in relation to (i) tree species variability, (ii) forest type and (iii) climatic factors including annual rainfall, seasonality, and maximum temperature. We use Bayesian modelling to calibrate the volume equations of 24 commercial tree species according to climatic variables, ranging large part of the Sudano-Guinean zone of West Africa, from Sierra Leone to Ghana. Given that competition for water and light, is not as well controlled in natural forests as it is in plantations, we assessed the impact of stand types on bole volume according to a south-north climatic gradient. By modifying the duration of droughts and heat stress, climate change negatively impacts the bole volume of the commercial species. So, the major realization is that forest management programs that do not allow for the interspecific variability of tree species as well as the annual maximum temperature are unlikely to provide reliable prediction of timber wood stocks in West Africa.Keywords : West Africa, Commercial tree species, Bole volume equation, Climate effects, Bayesian modelling.

Uma grande quantidade de equipamentos é acionada por motores elétricos que transmitem uma determinada rotação e torque por meio de sistemas de transmissão flexíveis, especificamente pelo uso de correias. Estas apresentam, no seu perfil transversal, o formato em V, mas também existem correias que, comparadas com as de formato em V, oferecem maior precisão de rotação entre o sistema de acionamento e o sistema acionado, ou seja, sincronizam a rotação durante a partida, o funcionamento e a parada da máquina, e é daí o nome do segundo tipo de correias de transmissão flexíveis, as correias síncronas ou sincronizadoras. Embora as correias sejam um elemento mecânico de suma importância na nossa atualidade, poucas atualizações foram encontradas na literatura consolidada dos cursos de Engenharia Mecânica, forçando em alguns casos a seguir o procedimento de cálculo errado ou desatualizado para a seleção de um tipo de correia, levando em consideração o que hoje se encontra disponível no mercado. Nesse sentido, esta publicação busca apresentar os cálculos consolidados da literatura acadêmica para a seleção correta de uma correia flexível e atualizar os mesmos com gráficos e fatores padronizados pelos principais fabricantes desse tipo de elemento mecânico. Também são abordadas as principais normas internacionais usadas para a fabricação de correias e suas respectivas polias. Finalmente, com o intuito de consolidar o procedimento de cálculo de uma correia de transmissão, é apresentado um estudo de caso que busca a seleção da melhor correia flexível.

No current treatment options were successful in containing the ongoing pandemic COVID-19 caused by SARS-CoV-2. It is essential to understand the molecular players of SARS-CoV-2 to find a suitable treatment method and to develop an effective antiviral drug as early as possible. Global researchers have undertaken accelerated structural studies of key proteins involved in host-virus interaction, replication, and transcription. In silico studies support structural biologist with preliminary information to efficiently drive further studies and characterization. From the genome sequence, most SARS-CoV-2 annotated ORF has a conserved sequence similar to SARS-CoV-1, except for ORF8 and ORF10. The function of ORF8 protein in SARS-CoV-2 is uncertain. Herein, we had modelled the ORF8 protein and studied its putative function using various substrates as a probe to determine its biological significance. The modelled SARS-CoV-2 (mORF87A) protein shows IgG characteristic folds and thus may belong to IgG superfamily. Further, we studied the binding efficacy of various antiviral drugs against the modelled ORF8 of SARS-CoV-2 (mORF8) to repurpose the drug and to use them as a probe to study its function by studying the binding/active sites interaction. Remdesivir had the highest binding affinity to ORF8 protein of SARS-CoV-2. The high affinity of the adenosine analogue yields critical information about the non-canonical RNA dependent RNA polymerase (RdRp) function of ORF8 protein. We hypothesize that the ORF8 protein may be a non-canonical RdRp in SARS-CoV-2 with ability to bind to canonical nsp12 complex.

Geometric phases appear as holonomies in principal bundles over quantum state spaces. In this work, we consider the case when the principal bundle itself is a Lie group and the quantum space of states a homogeneous space of that group.  This structure allows the application of the theory of nonlinear realizations of symmetry for the construction non-Abelian geometric phases corresponding to this bundle structure.  When the quantum state space is the complex Grassmann manifold U(N)/(U(N-k) × U(k)), we identify the total non-Abelian Aharonov-Anandan phase as the U(k)-valued cocycle of the U(N)  action on the Grassmann manifold . We describe generalizations of this result in two cases:  1) the case of isospectral dynamics of mixed states,  2) the case of non-self adjoint dynamics over the Grassmannian.

Background The coronavirus disease 2019 (COVID-19) pandemic has resulted in profound health challenges across the globe. Pharmacists’ readiness to cope with the pandemic is critical in supporting and sustaining the healthcare workforce to meet the challenges.Objective This study aims to examine community pharmacists’ views on their work environment, policies, and preparedness for safe retail patronage to prevent the transmission of COVID-19 and assess the variables influencing coping strategies during the pandemic.Setting An online survey of pharmacists practicing in community pharmacy setting in Malaysia.Method A questionnaire-based, cross-sectional study was conducted in Malaysia to evaluate coping strategies of community pharmacists and pharmaceutical services provided during COVID-19 pandemic. Between May 1 and July 31, 2020, the questionnaire was distributed to pharmacists working in community setting nationwide utilizing a snowball sampling method. Main outcome measure Community pharmacists’ perceptions on safety, resilience, organizational support, and pharmaceutical services offered during COVID-19 pandemic.Results A total of 217 pharmacists participated in the study. The vast majority of community pharmacists reported a positive outlook and were able to balance working with self-care during this period. Most reported to have access to personal protective equipment such as gloves and hand sanitizers. A large proportion of community pharmacies also installed physical barriers in doorways or in front of the counter, put markings on the ground to section areas to ensure physical distancing, and controlled the number of customers who could access the pharmacy during this period. Innovations reported to be implemented included teleconsultations and providing curb-side or drive-through delivery and pickup services.  Conclusion The findings suggest the frontline and essential roles of community pharmacists in delivering pandemic responses, creating the opportunity to determine areas where community pharmacy services can be incorporated to strengthen the public health system and improve patient health outcomes.

ToC Figure

Following the 1st release of the “Emerging PV reports” , the best achievements in the performance of emerging photovoltaic devices in diverse emerging photovoltaic research subjects are summarized, as reported in peer-reviewed articles in academic journals since August 2020. Updated graphs, tables and analyses are provided with several performance parameters, e.g. power conversion efficiency, open-circuit voltage, short-circuit current density, fill factor, light utilization efficiency, and stability test energy yield. These parameters are presented as a function of the photovoltaic bandgap energy and the average visible transmittance for each technology and application, and are put into perspective using, e.g., the detailed balance efficiency limit. The 2nd instalment of the“Emerging PV reports” extends the scope towards tandem solar cells and presents the current state of the art in tandem solar cell performance for various material combinations.

Este trabajo estudia la asociación que existe entre el nivel educativo y la interrupción legal del embarazo mediante la implementación de una serie de modelos del tipo logit. Utilizando una muestra de más de 70,000 mujeres de entre 11 y 53 años de edad para el periodo comprendido entre enero 2016 y mayo 2020, se encuentra que las mujeres más educadas son más propensas a abortar por convicción y no por necesidad y/o presión social. Además, se muestra que existen otros factores relacionados al aborto inducido, tales como el acceso a los servicios de salud, la remuneración en el trabajo, así como el uso de anticonceptivos, la edad de inicio de la vida sexual, el número de hijos, el número de abortos previos y la religión. El análisis confirma varios de los resultados obtenidos previamente en la literatura empírica y documental y aporta al debate sobre la despenalización sobre el aborto en México.

This is a review of the article "It’s Time to Talk About HPC Storage: Perspectives on the Past and Future," for the Leadership Computing department.Comments:Great article! I have only a few small suggestions for clarity/readability below. Abstract: suggest changing "especially as relates to the use of HPC" to "especially related to the use of HPC"paragraph 2: " ORNL Health Data Sciences Institute" -> "Oak Ridge National Laboratory (ORNL) Health Data Sciences Institute"Fig 2 caption: "Each access must traverse multiple distinct protocol hops, with its own interrupt processing, buffering, handshaking, serialization, and access control conventions  " The "its" is ambiguous here, suggest " Each access must traverse multiple distinct protocol hops, where each protocol hop has its own interrupt processing, buffering, handshaking, serialization, and access control conventions ." First paragraph in section "Emerging Challenges in HPC Storage": " Specifically, storage servers were designed to mediate all access to hard drives. By doing so, they could shape traffic (e.g., serializing and batching), buffer data (e.g., caching based on locality), and process I/O requests on more powerful host CPUs (e.g., handling interrupts, packing and unpacking Remote Procedure Call (RPC) requests, and enforcing authorization) to make the most of hard drive capabilities."  Suggest a couple filler words for clarity: " Specifically, storage servers were designed to mediate all access to hard drives. By doing so, they could shape traffic (e.g., by serializing and batching requests), buffer data (e.g., through caching based on locality), and process I/O requests on more powerful host CPUs (e.g., by handling interrupts, packing and unpacking Remote Procedure Call (RPC) requests, and enforcing authorization) to make the most of hard drive capabilities.    "Subsection headers throughout use inconsistent capitalization. I am not certain on the magazine style preference but from the department template it looks like capitalizing the first word and lowercase for the rest of the words is preferred for subsections, e.g., "Low Latency access to Storage" => "Low latency access to storage" In the paragraph beginning " From a device interface perspective, storage system", suggest adding a comma to this clause between "computation" and "reducing": "...  that affects device performance and cost, and as storage becomes disaggregated from computation, reducing data movement between the device and host becomes crucial.    "Same paragraph as above comment, for sentence "...     but recently most storage abstraction innovation has occurred elsewhere, with cloud service providers offering column stores, document stores, key-value stores, streaming data infrastructure, and object stores just to name a few options." Suggest rewording slightly to "...      but recently most storage abstraction innovation has occurred elsewhere, with cloud service providers offering numerous options including column stores, document stores, key-value stores, streaming data infrastructure, and object stores." Or maybe it would be clearer with a comma before "just to name a few options."

Copyright © 2020-2021, the authors. AH: ORCiD 0000-0002-0335-984XYW: ORCiD 0000-0001-5903-9370CD: ORCiD 0000-0002-7212-9554

Bacteria-mediated drug delivery systems comprising nanotherapeutics conjugated onto bacteria synergistically augment the efficacy of both therapeutic modalities in cancer therapy. Nanocarriers preserve therapeutics' bioavailability and reduce systemic toxicity, while bacteria selectively colonize the cancerous tissue, impart intrinsic and immune-mediated antitumor effects, and propel nanotherapeutics interstitially. The optimal bacteria-nanoparticle (NP) conjugates would carry the maximal NP load with minimal motility speed hindrance for effective interstitial distribution. Furthermore, a well-defined and repeatable NP attachment density distribution is crucial to determining these biohybrid systems' efficacious dosage and robust performance. Herein, we utilized our Nanoscale Bacteria-Enabled Autonomous Delivery System (NanoBEADS) platform to investigate the effects of assembly process parameters of mixing method, volume, and duration on NP attachment density and repeatability. We also evaluated the effect of linkage chemistry and NP size on NP attachment density, viability, growth rate, and motility of NanoBEADS. We show that the linkage chemistry impacts NP attachment density while the self-assembly process parameters affect the repeatability and, to a lesser extent, attachment density. Lastly, the attachment density affects NanoBEADS' growth rate and motility in an NP size-dependent manner. These findings will contribute to the development of scalable and repeatable bacteria-nanoparticle biohybrids for applications in drug delivery and beyond. Corresponding author(s) Email:  behkam@vt.edu  

Figure S1Experimental system: (A) overall view and (B) generator part.