We report a case of TEN probably related to Pristinamycin

The classic chancre of primary syphilis is painless and frequently neglected. We present a 20-year-old male complaining of red, tender, enlarging, skin lesions on the forehead, left nose, and left forearm for almost 2 months with systemic symptoms of secondary syphilis, granulomatous type.

Streptococcal toxic shock syndrome (STSS) has a high mortality rate, and most patients die within a few days of onset. We report an elderly patient with STSS, necrotizing fasciitis and septic shock caused by group G Streptococcus (GGS) who was successfully treated with multidisciplinary therapy.

Tens of millions of our own kind are killed by diseases in spite of the laudable effort of our healthcare teams every single year that the problem of immunity remains unsolved. But this problem is not longstanding because of the complexity of the nature of immunity but rather because we have been trying to obtain the knowledge we require to solve problems from theories that are logically deduced from observations when such knowledge can only be obtained from theories that are obtained with a method that requires reality to be illustrated and deductions to be made only for the purpose of knowing whether or not we have obtained the knowledge we seek from the results of our illustrations through the agreement or disagreement between facts and the consequences we have deduced from such results. The most influential among the theories of immunity is that which Ilya Mechnikov logically deduced from inflammatory phenomena in which phagocytosing cells that envelope and store foreign entities are brought to sites of cell death even in the absence of pathogens. This theory of immunity aimed to find proof for the logical deduction in which Pasteur and co-workers proposed the mechanism by which

Various conditions may mimic osteosarcoma. The differential diagnosis of osteosarcoma is broad. A proper history, examination, diagnostic imaging studies, and pathological analysis are essential to establish the precise diagnosis. This case report serves to illustrate the significance of recognizing similarities and other rare features to prevent late or misdiagnosis.

This report describes a case of aseptic meningitis suspected of having positive ocular globe compression sign in a 33-year-old man who was diagnosed only after repeated lumbar puncture. We highlight the importance of repeat lumbar puncture and the clinical value of ocular globe compression sign in suspecting aseptic meningitis.

Coronavirus disease is an infectious disease caused by newly discovered corona virus This case series was conducted in 11 Asian pregnant women. Clinical symptoms, pregnancy complications, medication used, maternal and neonatal outcomes and fatality rate were investigated.

we reported a case of skin and soft tissue infection caused by Yokenella regensburgei in a 71-year-old Chinese female patient without underlying diseases. We also reviewed published case reports from worldwide literature and summerized the risk factors of Y. regensburgei.

We report a modified minimally invasive surgery for thoracic pyogenic spondylitis by single-stage posterior fixation with curettage of the spinal anterior segments and autogenous iliac bone grafting using a separate posterolateral approach. This surgical method avoids contamination of spinal implants by maintaining a muscular barrier from the curettage/grafting site.

From 2016 to 2021, two cases of rabies encephalitis were diagnosed and hospitalized at the Kiffa hospital center. Neither of them had started the rabies vaccination after the dog bites before symptoms appeared. In countries where rabies still occurs, health workers should be trained for an efficient management of dog.

Leishmaniasis is a common cause of pancytopenia and hepatosplenomegaly in tropical and sub-tropical regions. A high index of suspicion is required to diagnose and manage patients with leishmaniasis. History of travel should always be elicited in patients with suggestive clinical presentation.

Herpes simplex encephalitis (HSE) is the most common type of sporadic encephalitis that inflicts high rates of morbidity and mortality. Differentiating a progressing encephalitis syndrome from a lobar hemorrhage as a complication presents a challenge and requires great vigilance and insight on part of the treating physician.

Malakoplakia is an uncommon granulomatous disease that occurs in immunocompromised individuals. It's thought to be caused by macrophagic bactericidial defect. We report a rare case of breast malakoplakia in a pregnant 35 ears-old woman that mimicked malignancy.

Reality has failed to agree with the expectation that vaccines will solve the COVID-19 problem by preventing onward transmission of the coronavirus known as SARS-CoV-2, which followed logical deductions from inflammatory phenomena in which Mechnikov and his contemporaries described immunity as originating from the elimination of pathogens by a system of cells and substances that has since been named the immune system. But upon illustrating the reality in which we are protected from the pathological manifestations that occur in response to the pathogen in immunological phenomena, it was found to be that in which the pathogen does not cause such pathological manifestations through effects that are due to its mere presence but rather through effects that are due to its influence on pathological mechanisms so that immune mechanisms do not protect us from such pathological manifestations by eliminating the pathogen but rather by making asymptomatic hosting of the pathogen possible. And such protection, which occurs in spite of the presence of the pathogen when the conditions from which it originates are present, is obtained by means of infection with the same pathogen through the attenuation of its

Nowadays apparently harmless Candida species especially rare ones, cause a rising number of infections. We report the first case of conjunctivitis due to Candida metapsilosis obtained from the eye discharge of 40-day-old girl with congenital heart disease admitted in the ICU. The isolate was resistant to fluconazole, anidulafungin and micafungin.

Kaposi's sarcoma is a common cancer associated with HIV infection. Since the COVID-19 pandemic, the prevalence of this pathology has increased. We report a case of a 33-year-old patient who presented with Kaposi's sarcoma associated with Covid-19 and HIV coinfection. It promotes the progression of cancers and increases mortality.

Late complications of COVID -19 infection are as important as the acute phase problems . A young woman with a history of COVID-19 infection and concomitant visual problems was admitted with exacerbation of dyspnea . During the admission, pulmonary embolism , myocarditis and fungal endocarditis were detected .

Recently spontaneous tension pneumomediastinum (PTM), pneumothorax (PT), and subcutaneous emphysema (SE) were reported as infrequent complications in COVID-19 patients. Early diagnosis and treatment could save the patients since these complications are related to poor prognosis and prolonged hospitalization. Here we report these complications in an Iranian patient.

Infective endocarditis rarely presents with cutaneous manifestations due to earlier diagnosis and treatment. We present a case of a middle-aged male patient presenting with an erythematous papular rash in the upper extremities and left knee, further progressing into painful ulcers.

Herein, we report a case of VAIHS with atypical clinical presentation of perianal abscess, fistula fever and bicytopenia including pathogenic ADA2 mutation suggesting that ADA2 deficiency be considered as a differential diagnosis of enlarging cutaneous abscess with no evidence of wound healing in the setting of leukopenia and neutropenia.

Objectives To summarise current practices in the diagnosis and management of Deep Neck Space Infections (DNSIs) To inform future studies in developing a framework in the management of DNSIs Design This review was registered on PROSPERO (CRD42021226449) and reported in line with PRISMA guidelines. All studies from 2000 that reported the investigation or management of DNSI were included. The search was limited to English language only. Databases searched included AMED, Embase, Medline and HMIC. Quantitative analysis was undertaken with descriptive statistics and frequency synthesis with 2 independent reviewers. A qualitative narrative synthesis was conducted using a thematic analysis approach. Setting Secondary or Tertiary Care centres that undertook management of Deep Neck Space Infections. Participants All adult patients with a deep neck space infection. Main outcome measures The role of imaging, radiologically guided aspiration and surgical drainage in DNSIs. Results 60 studies were reviewed. 31 studies reported on imaging modality, 51 studies reported treatment modality. Aside from a single RCT all other studies were observational (n=25) or case series (n=36). CT was used to diagnose DNSI in 78% of patients, Mean percentage of management with open surgical drainage was 81% and 29.4% for radiologically guided aspiration. Qualitative analysis identified 7 major themes were identified on DNSI. Conclusion There are limited methodologically rigorous studies investigating DNSIs. CT imaging was the most used imaging modality. Surgical drainage was commonest treatment choice. Areas of further research on epidemiology, reporting guidelines and management are required.

Neuroschistosomiasis is a rare entity, it can cause cerebral or spinal cord involvement. high clinical suspicion is needed to diagnose it and rapid treatment is needed to prevent complications.

Aim: To evaluate the treatments used in patients diagnosed with SARS-CoV-2 infection hospitalized in critical care service, through a prescription indication study. Methods: A longitudinal observational study of medication use, of the indication-prescription type with elements of the therapeutic scheme and practical consequences, was carried out. The sample was characterized from the sociodemographic, clinical, and pharmacotherapeutic points of view. The prescription was evaluated through the indicators: indication, therapeutic scheme, treatment individualization, and drug combinations. The detected adverse reactions were classified according to their causality by the Naranjo Algorithm, their severity, their clinical significance, and according to their mechanism by Rawlins and Thompson. Results: In the sample (N=77), the male gender predominated (79%) between 27-59 years old (64%), alcohol consumer (62%), hypertensive (33%) with long hospital stay (51%). 417 medications were analyzed, being antibiotics (50.6%) being the most prescribed. 73.4% of the therapeutic schemes were correct, however, 26.6% had problems with the therapeutic schemes due to the use of incorrect doses, intervals, and duration of treatment, as well as risky interactions. Two probable adverse reactions were detected, mild, non-serious, and type A and B according to Rawlins and Thompson. Conclusions: The results obtained will allow the pharmaceutical professional to create risk matrices that guarantee a timely intervention in the health team to contribute to the rational and safe use of medicines in patients infected with SARS-CoV-2.

We present the case of a previously healthy 36-year-old male with right eye discomfort, associated diplopia and dizziness as the primary clinical picture, seven days after a booster vaccination with the ChAdOx1-S (Oxford/AstraZeneca) COVID-19 vaccine.