This article introduces briefly current status of the Covid-19 pandemic and discusses “antidotes” of coronavirus (SARS-CoV-2 and its variants), that is, “ISISI” barriers from locals, nations or regions to the globe, namely, [Isolation with Masks, Unit protective clothing, Stay at “home”, and Travel restriction (MUST); Screening and testing; Individual immunity by healthy E(e)SEEDi lifestyle, bio-agents (chemical agents, convalescent plasma, neutralizing antibody, and Chinese medicine), and vaccination; Social and medical supports; International cooperation and information sharing]. Since there are several major coronavirus variants with more infectious, such as Delta and Omicron, many more cases with cardiac injury and cardiac arrest need better cardiovascular prevention and protection. With further understanding of the pathogenesis of Covid-19 and development of novel mRNA vaccines and discovery of new antiviral drugs, such as Molnupiravir and Paxlovid, people will do better in fighting against SARS-CoV-2 and its variants and cardiovascular protection in the pandemic and post-Covid-19 era.