Hoxb8 MC activation correlates better with sIgE than SPT.
To better understand if the data we generated using Hoxb8 MC passively sensitized with serum samples correlate with results from allergy diagnosis tests routinely performed in clinics, we performed linear regression analyses between the maximal activation of Hoxb8 MCs achieved upon allergen stimulation and either SPT or sIgE measurements. Only a weak (r=0.3), yet statistically significant, relationship between the Hoxb8 MC activation and SPT results was found (Fig. 3a ). Furthermore, there was a strong but imperfect correlation with sIgE measurements against peanut extract (r=0.91) and Ara h2 (r=0.81) (Fig. 3b-d ).