Another technique that has been around for a while is called cryo-Electron Microscopy (cryo-EM). The idea is to freeze (where the “cryo” name comes from) your protein on a support, called a grid (that is 3 mm wide), in what it would be its“natural” state. Then the protein is bombarded with electrons to make a picture, or movie, that reveals the shape of the protein. However, it became more popular only recently due to technological advances that allowed the recording of movies, rather than taking single pictures, to reduce the blurriness of the image. Think of it as recording a movie of a fast runner, rather than taking a single picture of him/her where any details of the runner would be blurred by the runner's motion: you take a movie and see how his/her legs move back and forth \cite{Cheng2015}.