AUTHOR CONTRIBUTIONS
Conceptualisation, J.S.C.; investigation, G.R. and J.N.; sample collection, C.P.O.; writing of the original draft preparation, G.R. and J.N.; review and editing, C.P.O.; V.G.; J.A.M.P., R.P. and J.S.C.; Visualization, J.A.M.P., R.P. and J.S.C.; Supervision: J. S. C., R. P., and J. A. M. P.; Funding Acquisition: J.S.C. All authors have read and agreed to the published version of the manuscript. All authors confirm that they have full access to all data in the study and accept the responsibility to submit the manuscript for publication.
ACKNOWLEDGEMENTS
This work was supported by FCT-Fundação para a Ciência e a Tecnologia through the CQM Base Fund-UIDB/00674/2020 and Programmatic Fund-UIDP/00674/2020; and by ARDITI-Agência Regional para o Desenvolvimento da Investigação Tecnologia e Inovação through the project M1420-01-0145-FEDER-000005-Centro de Química da Madeira-CQM+ (Madeira 14-20 Program). Giulia Riccio was supported by a PhD scholarship given by Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
The authors would like to thank all staff members at SESARAM, EPE-RAM and Dr. Nélio Mendonça Hospital for their help in conducting this research. We would also like to thank all the donors who participated in this study. The authors also acknowledge financial support from the Fundação para a Ciência e Tecnologia and Madeira 14-2020 program to the Portuguese Mass Spectrometry Network through the PROEQUIPRAM program M14-20 M1420-01-0145-FEDER-000008. Jorge A. M. Pereira was supported by a research contract given by Centro de Química da Madeira and Universidade da Madeira.